Everolimus-eluting stents: update on current clinical studies
| Autor: | Dominic J. Allocco, Anita A. Joshi, Keith D. Dawkins |
|---|---|
| Rok vydání: | 2011 |
| Předmět: |
medicine.medical_specialty
Everolimus eluting stent ComputingMethodologies_IMAGEPROCESSINGANDCOMPUTERVISION Xience V Biomedical Engineering Medicine (miscellaneous) Review Promus Element Restenosis Internal medicine medicine cardiovascular diseases Myocardial infarction Stent thrombosis Adverse effect Everolimus business.industry drug-eluting stents everolimus equipment and supplies medicine.disease Clinical trial Promus surgical procedures operative Cardiology business medicine.drug |
| Zdroj: | Medical Devices (Auckland, N.Z.) |
| ISSN: | 1179-1470 |
| DOI: | 10.2147/mder.s22043 |
| Popis: | Video abstract Video Everolimus-eluting stents (EES) have become the most commonly implanted coronary stents worldwide. This review describes and analyzes the clinical data supporting the use of EES, focusing primarily on published, randomized, controlled trials. Everolimus-eluting stents have been shown to have less restenosis, stent thrombosis, and periprocedural myocardial infarction compared with earlier generation paclitaxel-eluting stents (PES). Lower rates of adverse events for EES compared with PES were generally seen in all subgroups, with the notable exception of patients with diabetes mellitus. There have been fewer, randomized, clinical trials comparing EES with either sirolimus-eluting stents or zotarolimus-eluting stents, although very good results with EES have been observed in the trials that have been performed. Recent clinical trial data suggest that this excellent safety and efficacy profile is maintained in a next-generation EES designed to have improved mechanical properties and radiopacity. |
| Databáze: | OpenAIRE |
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