Expression of CYP and GST in human normal and colon tumor tissues
| Autor: | Mesude Işcan, Serpil Oguztuzun, S Göl, G Güler Simsek, Murat Kiliç, Busra Bozer, A Kaya Kocdogan, Hakan Buluş, A Oguz Ada, Pınar Kaygın |
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| Přispěvatelé: | [Belirlenecek], Kırıkkale Üniversitesi, Rektörlük |
| Rok vydání: | 2018 |
| Předmět: |
Male
0301 basic medicine Histology cytochrome P450 Colorectal cancer CYP1B1 Adenocarcinoma Gene Expression Regulation Enzymologic 03 medical and health sciences GSTP1 0302 clinical medicine Cytochrome P-450 Enzyme System Humans Medicine human Aged Glutathione Transferase Aged 80 and over colon 030102 biochemistry & molecular biology biology business.industry glutathione-S-transferase General Medicine Middle Aged medicine.disease digestive system diseases Staining Gene Expression Regulation Neoplastic Medical Laboratory Technology Glutathione S-transferase 030220 oncology & carcinogenesis Colonic Neoplasms Cancer research biology.protein Immunohistochemistry Female business GSTK1 smoking status |
| Zdroj: | Biotechnic & Histochemistry. 94:1-9 |
| ISSN: | 1473-7760 1052-0295 |
| DOI: | 10.1080/10520295.2018.1493220 |
| Popis: | Kilic, Murat/0000-0002-1377-2021; Oguztuzun, Serpil/0000-0002-5892-3735; Bozer, Busra/0000-0002-7280-4417; kaya kocdogan, arzu/0000-0002-3689-3061; Ada, Ahmet Oguz/0000-0001-9987-0572 WOS: 000458977400002 PubMed: 30092668 We investigated the immunohistochemical staining characteristics of cytochrome P450 1A1 (CYP1A1), CYPB1, CYP2E1, and glutathione S-transferase P1 (GSTP1), GSTT1, GSTO1, GSTK1 in colon tumor and surrounding normal colon tissues. Tissues were obtained from 47 patients with colon adenocarcinoma and the staining intensity of tumor and control tissues was compared. CYP1A1, CYP1B1, CYP2E1, GSTP1, GSTT1, GSTO1 and GSTK1 expressions in colon cancer cells were significantly greater than those in normal colon epithelial cells. No significant relation was found between the isoenzyme expressions and age, gender, smoking status, tumor grade and tumor stage. The higher expressions of CYP1A1, CYP1B1, CYP2E1, GSTP1, GSTO1, GSTT1 and GSTK1 in tumor than in normal colon tissues may be important for colon cancer progression and development. |
| Databáze: | OpenAIRE |
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