Effect of anti-inflammatory drugs and agents that elevate intracellular cyclic AMP on the release of toxic oxygen metabolites by phagocytes: Studies in a model of tissue-bound IgG
| Autor: | Richard B. Johnston, Joyce E. Lehmeyer |
|---|---|
| Rok vydání: | 1978 |
| Předmět: |
medicine.drug_class
Immunology Anti-Inflammatory Agents Inflammation Models Biological Anti-inflammatory Pathology and Forensic Medicine law.invention chemistry.chemical_compound Oxygen Consumption law Cyclic AMP medicine Immune Complex Diseases Immunology and Allergy Theophylline Hydrogen peroxide Chemiluminescence Phagocytes Superoxide chemistry Biochemistry Immunoglobulin G medicine.symptom Intracellular Histamine medicine.drug |
| Zdroj: | Clinical Immunology and Immunopathology. 9:482-490 |
| ISSN: | 0090-1229 |
| DOI: | 10.1016/0090-1229(78)90144-7 |
| Popis: | Human phagocytes in contact with fixed aggregated IgG emit a burst of oxygen-dependent chemiluminescence and release superoxide anion (O2−) and hydrogen peroxide. These oxygen metabolites are highly reactive and could contribute to inflammatory tissue damage. Methylprednisolone and prednisolone inhibited the generation of O2− and chemiluminescence by neutrophils and monocytes in this model. Indomethacin and aspirin had no definite effects in either assay. Chloroquine had no effect on O2 release but inhibited chemiluminescence. Agents that elevate intracellular levels of cyclic AMP (dibutyryl cyclic AMP, prostaglandins E1 and E2, and histamine) also decreased elaboration of O2− and chemiluminescence, especially when combined with theophylline. Agents that elevate intracellular cyclic GMP had no effect. Prednisolone and mediators of increased cyclic AMP also inhibited the production of O2− and chemiluminescence by eosinophils. These results are consistent with the possibility that the anti-inflammatory effects of corticosteroids are due in part to their ability to suppress the release of toxic oxygen metabolites from phagocytic cells at the sites of inflammation. They also suggest that elevation of intracellular levels of cyclic AMP could constitute a natural means of limiting inflammatory tissue damage. |
| Databáze: | OpenAIRE |
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