Mitochondrial abnormalities in patients with HIV-HCV co-infection as compared to patients with HCV mono-infection
| Autor: | Bruno Turlin, Faouzi Souala, Cédric Arvieux, Christian Michelet, Dominique Guyader, Pierre Rochcongar, Pierre Tattevin, Jocelyne Beillot, Jean-Marc Begue, Jean-Marc Chapplain |
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| Přispěvatelé: | Service des maladies infectieuses et réanimation médicale [Rennes] = Infectious Disease and Intensive Care [Rennes], CHU Pontchaillou [Rennes], Microenvironnement et remodelage, Centre Hospitalier Universitaire [Rennes]-Foie, métabolismes et cancer, Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique )-Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique ), Foie, métabolismes et cancer, the COREC (COmité de la REcherche Clinique), Centre Hospitalo-Universitaire de Rennes, Université de Rennes (UR)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique )-Université de Rennes (UR)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique ), Université de Rennes (UR)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique ) |
| Jazyk: | angličtina |
| Rok vydání: | 2011 |
| Předmět: |
Male
hepatitis C virus MESH: Histocytochemistry Biopsy HIV Infections Mitochondria Liver Hepacivirus Mitochondrion medicine.disease_cause Gastroenterology Incremental exercise Nucleoside Reverse Transcriptase Inhibitor MESH: Linear Models MESH: Biopsy 0302 clinical medicine Liver Function Tests cytochrome c oxidase MESH: Liver Function Tests Medicine Pharmacology (medical) MESH: Hepacivirus 030212 general & internal medicine MESH: Oxygen Consumption MESH: Middle Aged medicine.diagnostic_test Histocytochemistry MESH: HIV Respiratory chain complex virus diseases MESH: HIV Infections Middle Aged Hepatitis C 3. Good health mitochondria Infectious Diseases Liver biopsy Lactates Female 030211 gastroenterology & hepatology MESH: Mitochondria Liver Anaerobic exercise Adult medicine.medical_specialty respiratory chain reaction Hepatitis C virus exercise test MESH: Lactates 03 medical and health sciences Oxygen Consumption MESH: Cross-Sectional Studies Internal medicine Humans MESH: Hepatitis C MESH: Humans business.industry HIV MESH: Adult [SDV.MHEP.HEG]Life Sciences [q-bio]/Human health and pathology/Hépatology and Gastroenterology Virology MESH: Male Cross-Sectional Studies Linear Models business Complication MESH: Female |
| Zdroj: | HIV Clinical Trials HIV Clinical Trials, Thomas Land Publishers, 2011, 12 (1), pp.54-60. ⟨10.1310/hct1201-54⟩ HIV Clinical Trials, 2011, 12 (1), pp.54-60. ⟨10.1310/hct1201-54⟩ |
| ISSN: | 1528-4336 |
| DOI: | 10.1310/hct1201-54⟩ |
| Popis: | International audience; INTRODUCTION: Mitochondrial dysfunction is a classic complication of HIV infection and its treatment and has also been reported in hepatitis C virus (HCV)-infected patients. Little is known about interactions between both viruses on mitochondrial metabolism. METHODS: We performed a cross-sectional study of HCV-infected patients who underwent liver biopsy as part of their routine care. Mitochondrial function was assessed by (a) liver morphological (histology) and functional (spectro-photometry) studies, and (b) serum lactate kinetics, oxygen uptake, and anaerobic threshold measurement during standardized incremental exercise. Three predefined groups of patients were compared. RESULTS: Thirty-eight HCV-infected patients were included: 13 not HIV infected (group 1), 7 with HIV co-infection and low nucleoside reverse transcriptase inhibitor (NRTI) exposure (none over the last 2 years; group 2), and 18 with HIV co-infection and high NRTI exposure (group 3). On liver biopsies, respiratory chain complex IV activity was impaired, at 5 (2-7) nmol/min/mg substrates in group 1, 5 (3-8) in group 2, and 8 (2-13) in group 3 (normal values, 20-56). Maximal power output was diminished and anaerobic threshold occurred earlier in HIV-infected patients, regardless of NRTI exposure. CONCLUSION: HCV has deleterious effects on liver mitochondrial metabolism, notably on respiratory chain complex IV. No significant interaction with HIV was observed. |
| Databáze: | OpenAIRE |
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