A prospective comparison of locally made rapid urease test and histology for the diagnosis of Helicobacter pylori infection
| Autor: | FJ Branicki, John Wong, Kent-Man Chu, Ronnie T.P. Poon, Henry H. Tuen, Simon Law |
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| Rok vydání: | 1997 |
| Předmět: |
Male
medicine.medical_specialty Time Factors Biopsy Spirillaceae Rapid urease test Sensitivity and Specificity Gastroenterology Helicobacter Infections Predictive Value of Tests Positive predicative value Internal medicine medicine Humans Radiology Nuclear Medicine and imaging Prospective Studies Prospective cohort study Helicobacter pylori medicine.diagnostic_test biology business.industry Histology Middle Aged biology.organism_classification Urease Surgery Endoscopy Evaluation Studies as Topic Gastric Mucosa Female business |
| Zdroj: | Gastrointestinal Endoscopy. 46:503-506 |
| ISSN: | 0016-5107 |
| DOI: | 10.1016/s0016-5107(97)70004-x |
| Popis: | Background : A number of noncommercial preparations of urease test have been described. The present prospective study evaluated the accuracy of one such preparation for the diagnosis of Helicobacter pylori infection. Methods : From February 1996 to November 1996, all patients undergoing elective upper endoscopy in a single endoscopy facility were included. Three antral biopsy specimens were taken. Two specimens were subjected to histologic examination, and one specimen was placed into a “locally made rapid urease test” (LRUT). Results of histologic examinations were taken as standards for comparison. The final result of LRUT was obtained on scrutiny of color changes at 4 hours after the start of the test. Results : Two thousand three hundred sixteen patients (male/female = 1.5:1) with a mean age of 56.7 ± 0.4 years were included. Five hundred sixty-two patients (24.3%) had a history of eradication treatment for H. pylori . Nine hundred fifty-three patients (41.1%) were found to be positive for H. pylori on histologic examination. In patients in whom a history of eradication therapy was absent, the sensitivity, specificity, and positive and negative predictive values of the LRUT were 92.8%, 97.6%, 97.5%, and 93.0%, respectively. In patients with a history of eradication treatment, the corresponding figures were 76.1%, 99.6%, 96.2%, and 96.9%. Conclusions : The locally made rapid urease test provides a simple, safe, rapid, inexpensive, and accurate test for the diagnosis of H. pylori infection. (Gastrointest Endosc 1997;46:503-6.) |
| Databáze: | OpenAIRE |
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