An Enyne Cycloisomerization Approach to the Triple Reuptake Inhibitor GSK1360707F
| Autor: | Bing Liu, Elie A. Tabet, Mark B. Mitchell, Vassil I. Elitzin, Nicole Marie Deschamps, Matthew J. Sharp |
|---|---|
| Rok vydání: | 2010 |
| Předmět: |
Magnetic Resonance Spectroscopy
Molecular Structure Enyne Chemistry Stereochemistry Organic Chemistry Stereoisomerism Heterocyclic Compounds 2-Ring Chemical synthesis Catalysis chemistry.chemical_compound Cycloisomerization Isomerism Cyclization GSK1360707F Alkynes Neurotransmitter Uptake Inhibitors Gold Reuptake inhibitor Protecting group Azabicyclo Compounds Isomerization Platinum |
| Zdroj: | The Journal of Organic Chemistry. 76:712-715 |
| ISSN: | 1520-6904 0022-3263 |
| DOI: | 10.1021/jo102098y |
| Popis: | The triple reuptake inhibitor GSK1360707F was synthesized via an efficient and scalable route that features an enyne cycloisomerization reaction catalyzed by either Pt(II) or Au(I). Key aspects of this work such as the choice of the nitrogen protecting group and initial enantioselectivity studies are discussed. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|