Targeted Therapy in the Treatment of Pediatric Acute Lymphoblastic Leukemia-Therapy and Toxicity Mechanisms
| Autor: | Kinga Bednarz, Katarzyna Ostapinska, Joanna Zawitkowska, Monika Lejman, Kinga Kuśmierczuk |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
Oncology
Male medicine.medical_specialty Adolescent QH301-705.5 medicine.medical_treatment Antineoplastic Agents Review acute lymphoblastic leukemia Catalysis Targeted therapy Inorganic Chemistry Cell therapy Therapeutic approach Drug Delivery Systems Pediatric Acute Lymphoblastic Leukemia Internal medicine tyrosine kinase inhibitors medicine Humans Target therapy Molecular Targeted Therapy Biology (General) Physical and Theoretical Chemistry Precision Medicine Child QD1-999 Molecular Biology Spectroscopy business.industry molecular toxicity target therapy Organic Chemistry General Medicine Immunotherapy Precursor Cell Lymphoblastic Leukemia-Lymphoma Computer Science Applications Chemistry side effects Clinical research pediatric Child Preschool Toxicity Female immunotherapy business |
| Zdroj: | International Journal of Molecular Sciences International Journal of Molecular Sciences, Vol 22, Iss 9827, p 9827 (2021) |
| ISSN: | 1422-0067 |
| Popis: | Targeted therapy has revolutionized the treatment of poor-prognosis pediatric acute lymphoblastic leukemia (ALL) with specific genetic abnormalities. It is still being described as a new landmark therapeutic approach. The main purpose of the use of molecularly targeted drugs and immunotherapy in the treatment of ALL is to improve the treatment outcomes and reduce the doses of conventional chemotherapy, while maintaining the effectiveness of the therapy. Despite promising treatment results, there is limited clinical research on the effect of target cell therapy on the potential toxic events in children and adolescents. The recent development of highly specific molecular methods has led to an improvement in the identification of numerous unique expression profiles of acute lymphoblastic leukemia. The detection of specific genetic mutations determines patients’ risk groups, which allows for patient stratification and for an adjustment of the directed and personalized target therapies that are focused on particular molecular alteration. This review summarizes the knowledge concerning the toxicity of molecular-targeted drugs and immunotherapies applied in childhood ALL. |
| Databáze: | OpenAIRE |
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