Using arterial spin labeling to measure cerebrovascular reactivity in Moyamoya disease: Insights from simultaneous PET/MRI
| Autor: | Moss Y Zhao, Audrey P Fan, David Yen-Ting Chen, Yosuke Ishii, Mohammad Mehdi Khalighi, Michael Moseley, Gary K Steinberg, Greg Zaharchuk |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2022 |
| Předmět: |
arterial transit time
Neurology & Neurosurgery Arterial spin labeling cerebral blood flow Clinical Sciences Neurosciences Original Articles Cardiorespiratory Medicine and Haematology Magnetic Resonance Imaging cerebrovascular reactivity Moyamoya disease Neurology Clinical Research Cerebrovascular Circulation Positron-Emission Tomography Biomedical Imaging Humans Spin Labels Neurology (clinical) Moyamoya Disease Cardiology and Cardiovascular Medicine |
| Zdroj: | J Cereb Blood Flow Metab Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, vol 42, iss 8 |
| Popis: | Cerebrovascular reactivity (CVR) reflects the CBF change to meet different physiological demands. The reference CVR technique is PET imaging with vasodilators but is inaccessible to most patients. DSC can measure transit time to evaluate patients suspected of stroke, but the use of gadolinium may cause side-effects. Arterial spin labeling (ASL) is a non-invasive MRI technique for CBF measurements. Here, we investigate the effectiveness of ASL with single and multiple post labeling delays (PLD) to replace PET and DSC for CVR and transit time mapping in 26 Moyamoya patients. Images were collected using simultaneous PET/MRI with acetazolamide. CVR, CBF, arterial transit time (ATT), and time-to-maximum (Tmax) were measured in different flow territories. Results showed that CVR was lower in occluded regions than normal regions (by 68 ± 12%, 52 ± 5%, and 56 ± 9%, for PET, single- and multi-PLD PCASL, respectively, all p 2 > 0.35, p |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|