Instrumental analysis of finger tapping reveals a novel early biomarker of parkinsonism in idiopathic rapid eye movement sleep behaviour disorder
| Autor: | Evžen Růžička, Radim Krupicka, Zoltan Szabo, Petr Krýže, Slávka Neťuková, Tereza Duspivova, Petr Dusek, Karel Sonka, Jan Rusz, Ondřej Klempíř |
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| Rok vydání: | 2020 |
| Předmět: |
medicine.medical_specialty
Movement Rapid eye movement sleep Hypokinesia REM Sleep Behavior Disorder Objective assessment 03 medical and health sciences 0302 clinical medicine Physical medicine and rehabilitation Parkinsonian Disorders Rapid eye movement sleep behaviour disorder medicine Humans business.industry Parkinsonism Repetitive movements Parkinson Disease General Medicine medicine.disease 030228 respiratory system Finger tapping Tapping Biomarker (medicine) business Biomarkers 030217 neurology & neurosurgery |
| Zdroj: | Sleep Medicine. 75:45-49 |
| ISSN: | 1389-9457 |
| Popis: | Idiopathic rapid eye movement sleep behaviour (iRBD) is considered as a risk factor for Parkinson's disease (PD) development. Evaluation of repetitive movements with finger tapping, which serves as a principal task to measure the extent of bradykinesia in PD, may undercover potential PD patients. The aim of this study was to explore whether finger tapping abnormalities, evaluated with a 3D motion capture system, are already present in RBD patients.Finger tapping data was acquired using a contactless 3D motion capture system from 40 RBD subjects and compared to 25 de-novo PD patients and 25 healthy controls. Objective assessment of amplitude decrement, maximum opening velocity and their combination representing finger tapping decrement was performed in the sequence of the first ten tapping movements. The association between instrumental finger tapping data and semi-quantitative clinical evaluation was analyzed.While significant differences between PD and controls were found for all investigated finger tapping measures (p 0.002), RBD differed from controls in finger tapping amplitude (p = 0.004) and velocity (p = 0.007) decrement but not in maximal opening velocity. A significant relationship between the motor score from the Movement Disorders Society - Unified Parkinson's Disease Rating Scale and finger tapping decrement was shown for both patient groups, ie RBD (r = 0.36, p = 0.02) and PD (r = 0.60, p = 0.002).In our group of RBD patients we demonstrated amplitude decrement of repetitive movements, which may correspond with prodromal bradykinesia. Our findings suggest instrumental analysis of finger tapping abnormalities as a potential novel clinical marker reflecting subclinical motor disturbances in RBD. |
| Databáze: | OpenAIRE |
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