A survey on pulmonary pathogens and their antibiotic susceptibility among cystic fibrosis patients
Autor: | Aliakbar Sayyari, Mitra Ashayeri-Panah, Kourosh Sheibani, Majidreza Akbarizadeh, Ghamartaj Khanbabaee, Fatemeh Abdollahgorji, Nima Rezaei |
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Jazyk: | angličtina |
Předmět: |
Male
Microbiology (medical) Imipenem Adolescent medicine.drug_class Antibiotics lcsh:QR1-502 Respiratory tract Ceftazidime Biology Respiratory tract infections Gram-Positive Bacteria Azithromycin medicine.disease_cause lcsh:Microbiology Cystic fibrosis lcsh:Infectious and parasitic diseases Microbiology Disk Diffusion Antimicrobial Tests Gram-Negative Bacteria medicine Humans lcsh:RC109-216 infections Child Medicine(all) Products with antimicrobial action Pseudomonas aeruginosa Sputum Infant General Medicine Cross-Sectional Studies Infectious Diseases Amikacin Child Preschool Pharynx Vancomycin Female medicine.symptom medicine.drug |
Zdroj: | Brazilian Journal of Infectious Diseases, Vol 16, Iss 2, Pp 122-128 (2012) Brazilian Journal of Infectious Diseases, Vol 16, Iss 2, Pp 122-128 Brazilian Journal of Infectious Diseases v.16 n.2 2012 Brazilian Journal of Infectious Diseases Brazilian Society of Infectious Diseases (BSID) instacron:BSID Brazilian Journal of Infectious Diseases, Volume: 16, Issue: 2, Pages: 122-128, Published: APR 2012 |
ISSN: | 1413-8670 |
DOI: | 10.1016/S1413-8670(12)70292-1 |
Popis: | Objective: This study was performed to investigate frequency and antimicrobial susceptibility of pulmonary pathogens in cystic fibrosis (CF) patients. Methods: 129 pediatric patients with CF were enrolled in this cross-sectional study. Microbiological cultures were performed based on sputum or pharyngeal swabs. Antibiotic susceptibilities of the isolated bacteria were determined by the disk diffusion method. Results: The main infecting pathogens were Pseudomonas aeruginosa (38.8%), Klebsiella pneumoniae (11.6%) and Staphyloccus areus (9.3%), respectively. The most active antibiotics included rifampin (91.7% susceptibility), vancomycin (85%) and imipenem (83.5%). Emerging resistance against aminoglycosides was observed. Conclusion: Regarding in vitro susceptibility results, cyclic treatment of long-term oral azithromycin and inhaled tobramycin could prophylactically be applied, and during exacerbations, imipenem or ceftazidime in combination with an aminoglycoside such as amikacin could be considered the drugs of choice. Keywords: Cystic fibrosis, Respiratory tract infections, Products with antimicrobial action |
Databáze: | OpenAIRE |
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