In Vitro and In Vivo Activity of Amiodarone Against Ebola Virus
| Autor: | Huanying Zhou, Gene G. Olinger, Kathleen O’Loughlin, Joshua C. Johnson, Richard S. Bennett, Julia Michelotti, Anna N. Honko, Carol E. Green, Lisa E. Hensley, Yu Cong, Dawn M. Gerhardt, Steven E. Kern, Brit J. Hart, Lisa Evans DeWald, Jon C. Mirsalis, Peter B. Jahrling, Elena Postnikova, Julie Dyall |
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| Rok vydání: | 2018 |
| Předmět: |
Male
0301 basic medicine viruses Guinea Pigs 030106 microbiology Amiodarone Supplement Articles Pharmacology medicine.disease_cause Virus 03 medical and health sciences In vivo Chlorocebus aethiops medicine Animals Immunology and Allergy Channel blocker Vero Cells Ebola virus business.industry Lethal dose Cardiac arrhythmia Hemorrhagic Fever Ebola Ebolavirus Drug repositioning 030104 developmental biology Infectious Diseases Female business medicine.drug |
| Zdroj: | The Journal of Infectious Diseases. 218:S592-S596 |
| ISSN: | 1537-6613 0022-1899 |
| Popis: | At the onset of the 2013-2016 epidemic of Ebola virus disease (EVD), no vaccine or antiviral medication was approved for treatment. Therefore, considerable efforts were directed towards the concept of drug repurposing or repositioning. Amiodarone, an approved multi-ion channel blocker for the treatment of cardiac arrhythmia, was reported to inhibit filovirus entry in vitro. Compassionate use of amiodarone in EVD patients indicated a possible survival benefit. In support of further clinical testing, we confirmed anti-Ebola virus activity of amiodarone in different cell types. Despite promising in vitro results, amiodarone failed to protect guinea pigs from a lethal dose of Ebola virus. |
| Databáze: | OpenAIRE |
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