Psychiatric disorders in rapid-onset dystonia-parkinsonism
| Autor: | Jared F. Cook, Niki Boggs, Allison Brashear, Cynthia K. Suerken, Kathleen J. Sweadner, Alethea Amponsah, Laney S. Light, Laurie J. Ozelius, W. Vaughn McCall, Beverly M. Snively, Mark Stacy, Deborah F. Hill |
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| Rok vydání: | 2012 |
| Předmět: |
Adult
Male medicine.medical_specialty Heterozygote Adolescent Gene mutation Asymptomatic Rating scale Activities of Daily Living medicine Humans Psychiatry Aged Dystonia Aged 80 and over Psychiatric Status Rating Scales Mental Disorders Articles Middle Aged medicine.disease Substance abuse Mood Dystonic Disorders Anxiety Female Neurology (clinical) medicine.symptom Sodium-Potassium-Exchanging ATPase Psychology Dystonic disorder |
| Zdroj: | Neurology. 79(11) |
| ISSN: | 1526-632X |
| Popis: | Objective: Rapid-onset dystonia-parkinsonism (RDP) is caused by a variety of missense mutations in the ATP1A3 gene. Psychiatric comorbidity has been reported, although systematic examination of psychiatric disease in individuals with RDP is lacking. This study examines psychiatric morbidity for 23 patients with RDP in 10 families with family member control subjects and in 3 unrelated patients with RDP, totaling 56 individuals. Methods: Twenty-nine ATP1A3 mutation–positive individuals were examined; 26 exhibited motor symptoms (motor manifesting carrier [MMC]) and 3 did not (nonmotor manifesting carriers [NMC]). Twenty-seven ATP1A3 mutation-negative participants (noncarriers [NC]) were included. Rates of psychiatric illness for patients with RDP and related asymptomatic gene mutation carriers were compared with those for related nonmutation carriers. Outcome measures included the Unified Parkinson9s Disease Rating Scale, Burke-Fahn-Marsden Dystonia Rating Scale, Instrumental Activities of Daily Living, Composite International Diagnostic Interview, Structured Clinical Interview for DSM-IV , Hamilton Depression Scale, Hamilton Anxiety Scale, and Yale-Brown Obsessive-Compulsive Scale. Results: NMC participants did not report any history of psychiatric disorder. Findings in MMC and NC groups included anxiety (MMC 48, NC 41%), mood (MMC 50%, NC 22%), psychotic (MMC 19%, NC 0%), and substance abuse/dependence (MMC 38%, NC 27%). Conclusions: ATP1A3 mutations cause a wide spectrum of motor and nonmotor features. Psychotic symptoms tended to emerge before or concurrent with motor symptom onset, suggesting that this could be another expression of the ATP1A3 gene mutation. |
| Databáze: | OpenAIRE |
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