Positive association of personal distress with testosterone in opiate-addicted patients
| Autor: | Ralf Lichtinghagen, Stefan Bleich, Annemarie Heberlein, Katrin Stange, Eva Janke, Thomas Hillemacher, Mathias Krüger |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
Adult
Male medicine.medical_specialty media_common.quotation_subject Medicine (miscellaneous) Personal distress Empathy Interpersonal communication 03 medical and health sciences 0302 clinical medicine Cognition Stress Physiological Germany Humans Medicine Testosterone Psychiatry Saliva Schools Medical Empathic concern media_common Psychiatric Status Rating Scales business.industry Addiction Testosterone (patch) General Medicine Middle Aged Opioid-Related Disorders 030227 psychiatry Psychiatry and Mental health Clinical Psychology Cross-Sectional Studies Biomarker (medicine) Opiate Psychology Factor Analysis Statistical business Social psychology 030217 neurology & neurosurgery Biomarkers Stress Psychological Clinical psychology |
| Zdroj: | Suchttherapie. |
| ISSN: | 1439-989X |
| Popis: | Clinical studies report that substance addictions are associated with sociocognitive impairments. Regarding opiate-addicted patients, the few existing studies point to deficits in empathic abilities. Previous research suggests that testosterone might be a relevant biomarker of these impairments. The authors aimed to investigate whether opiate-addicted patients show specific impairments in emotional (empathic concern, personal distress) and cognitive empathy compared to healthy controls. Furthermore, the authors aimed to assess possible associations of testosterone levels with impaired empathic abilities in the patients' group. In this cross-sectional study, 27 opiate-addicted, diacetylmorphine-maintained patients (21 males, age mean 41.67 years, standard deviation 8.814) and 31 healthy controls (23 males, age mean 40.77 years, standard deviation 8.401) matched in age, sex, and educational level were examined. Cognitive and emotional empathy were measured via the German version of the Interpersonal Reactivity Index and salivary testosterone levels were assessed. The authors found higher personal distress scores (p0.01, d = 0.817) and higher testosterone (p0.001, d = 1.093) in the patients' group compared to controls. Moreover, a positive correlation was found between testosterone and personal distress among the patients' group (r = 0.399, p0.05). Opiate-addicted patients show specific impairments in emotional empathy, namely higher personal distress, which has clinical implications regarding social cognition rehabilitation and relapse prevention. The current data point toward testosterone as a possible biomarker for these sociocognitive impairments and suggest that high personal distress and high testosterone during withdrawal are possible markers for severe opiate addiction. |
| Databáze: | OpenAIRE |
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