Interest of extracellular vesicles in regards to lipid nanoparticle based systems for intracellular protein delivery
| Autor: | Anne Aubert-Pouëssel, Joël Chopineau, Jean-Marie Devoisselle, Marie Morille, Pierre Martineau, Khaled Elhady Mohamed, Laurence Guglielmi, Philippe Legrand, Sarah Le Saux |
|---|---|
| Přispěvatelé: | Institut Charles Gerhardt Montpellier - Institut de Chimie Moléculaire et des Matériaux de Montpellier (ICGM ICMMM), Ecole Nationale Supérieure de Chimie de Montpellier (ENSCM)-Centre National de la Recherche Scientifique (CNRS)-Université de Montpellier (UM)-Université Montpellier 1 (UM1)-Université Montpellier 2 - Sciences et Techniques (UM2)-Institut de Chimie du CNRS (INC), Institut de Recherche en Cancérologie de Montpellier (IRCM - U1194 Inserm - UM), CRLCC Val d'Aurelle - Paul Lamarque-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Montpellier (UM) |
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
[SDV.BIO]Life Sciences [q-bio]/Biotechnology
Cell Pharmaceutical Science Context (language use) 02 engineering and technology Extracellular Vesicles 03 medical and health sciences Drug Delivery Systems medicine Extracellular Animals Humans ComputingMilieux_MISCELLANEOUS 030304 developmental biology 0303 health sciences Liposome Chemistry Proteins [SDV.SP]Life Sciences [q-bio]/Pharmaceutical sciences 021001 nanoscience & nanotechnology Microvesicles medicine.anatomical_structure Membrane Liposomes Biophysics Nanoparticles Nanocarriers 0210 nano-technology Intracellular |
| Zdroj: | Advanced Drug Delivery Reviews Advanced Drug Delivery Reviews, Elsevier, 2021, pp.113837. ⟨10.1016/j.addr.2021.113837⟩ |
| ISSN: | 0169-409X |
| DOI: | 10.1016/j.addr.2021.113837⟩ |
| Popis: | Compared to chemicals that continue to dominate the overall pharmaceutical market, protein therapeutics offer the advantages of higher specificity, greater activity, and reduced toxicity. While nearly all existing therapeutic proteins were developed against soluble or extracellular targets, the ability for proteins to enter cells and target intracellular compartments can significantly broaden their utility for a myriad of exiting targets. Given their physical, chemical, biological instability that could induce adverse effects, and their limited ability to cross cell membranes, delivery systems are required to fully reveal their biological potential. In this context, as natural protein nanocarriers, extracellular vesicles (EVs) hold great promise. Nevertheless, if not present naturally, bringing an interest protein into EV is not an easy task. In this review, we will explore methods used to load extrinsic protein into EVs and compare these natural vectors to their close synthetic counterparts, liposomes/lipid nanoparticles, to induce intracellular protein delivery. |
| Databáze: | OpenAIRE |
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