Resolved 6,7,8,9-tetrahydro-N,N-dimethyl-3H-benz[e]indol-8-amine: central dopamine and serotonin receptor stimulating properties
| Autor: | L G Humber, Arvid Carlsson, Arne Svensson, Ekman A, A A Asselin, Håkan Wikström, Bengt Andersson, I Nilsson, Kjell A. Svensson, C Chidester |
|---|---|
| Rok vydání: | 1989 |
| Předmět: |
Male
Indoles Reserpine Stereochemistry Dopamine Agents Motor Activity Receptors Dopamine Structure-Activity Relationship Dopamine receptor D1 Isomerism Dopamine receptor D3 Dopamine receptor D2 TAAR1 Drug Discovery Animals 5-HT receptor Receptors Dopamine D2 Chemistry Receptors Dopamine D1 Cell Membrane Dopaminergic Brain Rats Inbred Strains Corpus Striatum Rats Receptors Serotonin 5-HT6 receptor Molecular Medicine Endogenous agonist |
| Zdroj: | Journal of Medicinal Chemistry. 32:2273-2276 |
| ISSN: | 1520-4804 0022-2623 |
| Popis: | The enantiomers of 6,7,8,9-tetrahydro-N,N-dimethyl-3H-benz[e]indol-8- amine (1a) were prepared and tested for their actions on central dopamine and serotonin (5-HT) receptors. The dopaminergic effects were shown to reside in the (1)-R enantiomer. It was shown that compound 1a and its (+)-R enantiomer possess potent central 5-HT1A receptor stimulating properties. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|