Agmatine produces antidepressant-like effects in two models of depression in mice
| Autor: | Jaime Lin, Andréa D.E. Zomkowski, Adair R.S. Santos, João B. Calixto, Ana Lúcia S. Rodrigues, Luciana Hammes |
|---|---|
| Rok vydání: | 2002 |
| Předmět: |
Male
Imipramine medicine.medical_specialty Agmatine Antidepressive Agents Tricyclic Receptors N-Methyl-D-Aspartate Mice chemistry.chemical_compound Internal medicine medicine Prazosin Animals Dose-Response Relationship Drug Depression General Neuroscience Antidepressive Agents Agmatinase Tail suspension test Yohimbine Disease Models Animal Endocrinology chemistry NMDA receptor Female Nitric Oxide Synthase human activities Behavioural despair test medicine.drug |
| Zdroj: | Neuroreport. 13:387-391 |
| ISSN: | 0959-4965 |
| DOI: | 10.1097/00001756-200203250-00005 |
| Popis: | Agmatine produces an antidepressant-like effect when assessed in the forced swimming test (FST) and in the tail suspension test (TST) in mice (dose range 0.01-50 mg/kg, i.p.), without accompanying changes in ambulation in an open-field. I.c.v. injection of agmatine (1-100 nmol/site) also reduced the immobility time in the FST. Agmatine significantly enhanced the anti-immobility effect of imipramine, but did not affect that of MK-801. The anti-immobility effect of agmatine assessed in the FST was not affected by pre-treatment with prazosin. In contrast, agmatine's antidepressant-like effect was completely prevented by pre-treatment of animals with yohimbine, GMP or L-arginine. Taken together these data demonstrate that agmatine elicited a significant antidepressant-like effect through a mechanism that seems to involve an interaction with NMDA receptors, the L-arginine-nitric oxide pathway and alpha2-adrenoceptors. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|