Recruitment methods in Alzheimer's disease research: general practice versus population based screening by mail
Autor: | Matti Viitanen, Kjell Sjøbrend, Torgeir Engstad, Samuel Hykkerud, Dag S. Halvorsen, Bjørn Straume, Fred Andersen |
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Rok vydání: | 2010 |
Předmět: |
Male
Gerontology Epidemiology General Practice Health Informatics Physical examination Disease law.invention Age Distribution Randomized controlled trial Alzheimer Disease law Surveys and Questionnaires medicine Humans Postal Service Sex Distribution lcsh:R5-920 VDP::Medisinske Fag: 700::Helsefag: 800::Samfunnsmedisin sosialmedisin: 801 medicine.diagnostic_test Descriptive statistics Norway business.industry Patient Selection Cognition medicine.disease Cognitive test Female VDP::Medical disciplines: 700::Health sciences: 800::Community medicine Social medicine: 801 Alzheimer's disease lcsh:Medicine (General) business Research Article |
Zdroj: | BMC Medical Research Methodology, Vol 10, Iss 1, p 35 (2010) BMC Medical Research Methodology |
ISSN: | 1471-2288 |
Popis: | Background In Alzheimer's disease (AD) research patients are usually recruited from clinical practice, memory clinics or nursing homes. Lack of standardised inclusion and diagnostic criteria is a major concern in current AD studies. The aim of the study was to explore whether patient characteristics differ between study samples recruited from general practice and from a population based screening by mail within the same geographic areas in rural Northern Norway. Methods An interventional study in nine municipalities with 70000 inhabitants was designed. Patients were recruited from general practice or by population based screening of cognitive function by mail. We sent a questionnaire to 11807 individuals ≥ 65 years of age of whom 3767 responded. Among these, 438 individuals whose answers raised a suspicion of cognitive impairment were invited to an extended cognitive and clinical examination. Descriptive statistics, chi-square, independent sample t-test and analyses of covariance adjusted for possible confounders were used. Results The final study samples included 100 patients recruited by screening and 87 from general practice. Screening through mail recruited younger and more self-reliant male patients with a higher MMSE sum score, whereas older women with more severe cognitive impairment were recruited from general practice. Adjustment for age did not alter the statistically significant differences of cognitive function, self-reliance and gender distribution between patients recruited by screening and from general practice. Conclusions Different recruitment procedures of individuals with cognitive impairment provided study samples with different demographic characteristics. Initial cognitive screening by mail, preceding extended cognitive testing and clinical examination may be a suitable recruitment strategy in studies of early stage AD. Clinical Registration ClinicalTrial.gov Identifier: NCT00443014 |
Databáze: | OpenAIRE |
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