Increased circulating platelet–leucocyte complexes in patients with primary Raynaud's phenomenon and Raynaud's phenomenon secondary to systemic sclerosis: a comparative study
| Autor: | Burhan Turgut, Özden Vural, Ömer Nuri Pamuk, Muzaffer Demir, Necati Çakir, Gülsüm Emel Pamuk |
|---|---|
| Rok vydání: | 2007 |
| Předmět: |
Adult
Male medicine.medical_specialty P-selectin Gastroenterology Scleroderma Internal medicine Leukocytes Humans Medicine Platelet Platelet activation Autoimmune disease Scleroderma Systemic integumentary system business.industry Raynaud Disease Hematology General Medicine Middle Aged Flow Cytometry Platelet Activation medicine.disease Pulmonary hypertension Connective tissue disease P-Selectin Endocrinology Female business Iloprost medicine.drug |
| Zdroj: | Blood Coagulation & Fibrinolysis. 18:297-302 |
| ISSN: | 0957-5235 |
| DOI: | 10.1097/mbc.0b013e328010bd05 |
| Popis: | Platelet activation and circulating platelet-leucocyte complexes increase in vascular ischemic events and autoimmune inflammatory diseases. Platelet activation markers and platelet-leucocyte complexes were evaluated in primary Raynaud's phenomenon (RP) and in RP secondary to systemic sclerosis (SSc). Whole-blood flow cytometry was utilized to quantify CD62P, platelet microparticles (PMP), platelet-monocyte complexes (PMC) and platelet-neutrophil complexes (PNC) in primary RP and in SSc patients with secondary RP. SSc patients with secondary RP had significantly higher platelet CD62P expression than primary RP patients and controls (P = 0.017 and 0.004, respectively). Primary and secondary RP patients had higher mean PMC and PNC levels than controls (all Por = 0.001). PMP level in SSc patients with pulmonary hypertension was significantly higher than in others (P = 0.048). All parameters were similar in SSc patients with and without digital ulcers, aspirin-users and nonusers (P0.05). CD62P level decreased significantly after iloprost administration in four patients with digital ulcers (16.1 +/- 17.4 vs 7.4 +/- 3.8%, P = 0.03). Our results suggest there is platelet-leucocyte complex formation in RP, and, despite antithrombotic therapy, platelet activation and platelet-leucocyte interaction are ongoing in SSc. This is important as it might have potential therapeutic implications with respect to using antiplatelet drugs in SSc. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|