A dynamic, sex-specific expression pattern of genes regulating thyroid hormone action in the developing zebra finch song control system
| Autor: | Raymaekers, Sander R, Verbeure, Wout, Ter Haar, Sita M, Cornil, Charlotte A, Balthazart, Jacques, Darras, Veerle M, Leerstoel Bolhuis, Helmholtz Institute, Experimental Psychology (onderzoeksprogramma PF), Afd Psychologische functieleer |
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| Přispěvatelé: | Leerstoel Bolhuis, Helmholtz Institute, Experimental Psychology (onderzoeksprogramma PF), Afd Psychologische functieleer |
| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
Male medicine.medical_specialty Thyroid Hormones Arcopallium Thyroid hormones Deiodinase DIO2 Neovascularization Physiologic Development Iodide Peroxidase 03 medical and health sciences 0302 clinical medicine Endocrinology Song control system Internal medicine medicine Animals Zebra finch Analysis of Variance Sex Characteristics Receptors Thyroid Hormone biology Brain Gene Expression Regulation Developmental Membrane Transport Proteins 030104 developmental biology nervous system biology.protein behavior and behavior mechanisms Nidopallium Animal Science and Zoology Neuroplasticity Female Finches Vocalization Animal Neural development 030217 neurology & neurosurgery Hormone |
| Zdroj: | General and Comparative Endocrinology, 240, 91. Academic Press Inc. |
| ISSN: | 1095-6840 0016-6480 |
| Popis: | The zebra finch (Taeniopygia guttata) song control system consists of several series of interconnected brain nuclei that undergo marked changes during ontogeny and sexual development, making it an excellent model to study developmental neuroplasticity. Despite the demonstrated influence of hormones such as sex steroids on this phenomenon, thyroid hormones (THs) - an important factor in neural development and maturation - have not been studied in this regard. We used in situ hybridization to compare the expression of TH transporters, deiodinases and receptors between both sexes during all phases of song development in male zebra finch. Comparisons were made in four song control nuclei: Area X, the lateral magnocellular nucleus of the anterior nidopallium (LMAN), HVC (used as proper name) and the robust nucleus of the arcopallium (RA). Most genes regulating TH action are expressed in these four nuclei at early stages of development. However, while general expression levels decrease with age, the activating enzyme deiodinase type 2 remains highly expressed in Area X, HVC and RA in males, but not in females, until 90days post-hatch (dph), which marks the end of sensorimotor learning. Furthermore, the L-type amino acid transporter 1 and TH receptor beta show elevated expression in male HVC and RA respectively compared to surrounding tissue until adulthood. Differences compared to surrounding tissue and between sexes for the other TH regulators were minor. These developmental changes are accompanied by a strong local increase in vascularization in the male RA between 20 and 30dph but not in Area X or HVC. Our results suggest that local regulation of TH signaling is an important factor in the development of the song control nuclei during the song learning phase and that TH activation by DIO2 is a key player in this process. |
| Databáze: | OpenAIRE |
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