Development of an environmentally more benign reflectometric method for the determination of metoclopramide in pharmaceutical formulations
| Autor: | Keity Margareth Doretto, M. A. Gotardo, Leonardo Pezza, Helena Redigolo Pezza |
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| Přispěvatelé: | Universidade Estadual Paulista (Unesp) |
| Jazyk: | portugalština |
| Rok vydání: | 2010 |
| Předmět: | |
| Zdroj: | Química Nova, Volume: 33, Issue: 2, Pages: 461-465, Published: 2010 SciELO Repositório Institucional da UNESP Universidade Estadual Paulista (UNESP) instacron:UNESP Química Nova v.33 n.2 2010 Química Nova Sociedade Brasileira de Química (SBQ) instacron:SBQ |
| ISSN: | 0100-4042 |
| Popis: | Submitted by Guilherme Lemeszenski (guilherme@nead.unesp.br) on 2013-08-22T18:48:49Z No. of bitstreams: 1 S0100-40422010000200039.pdf: 522843 bytes, checksum: 0f20f2fcc212e4ed940ae4f281938995 (MD5) Made available in DSpace on 2013-08-22T18:48:49Z (GMT). No. of bitstreams: 1 S0100-40422010000200039.pdf: 522843 bytes, checksum: 0f20f2fcc212e4ed940ae4f281938995 (MD5) Previous issue date: 2010-01-01 Made available in DSpace on 2013-09-30T19:38:53Z (GMT). No. of bitstreams: 2 S0100-40422010000200039.pdf: 522843 bytes, checksum: 0f20f2fcc212e4ed940ae4f281938995 (MD5) S0100-40422010000200039.pdf.txt: 29986 bytes, checksum: 34751217eaffd2926281847a7376ad8d (MD5) Previous issue date: 2010-01-01 Submitted by Vitor Silverio Rodrigues (vitorsrodrigues@reitoria.unesp.br) on 2014-05-20T14:21:02Z No. of bitstreams: 2 S0100-40422010000200039.pdf: 522843 bytes, checksum: 0f20f2fcc212e4ed940ae4f281938995 (MD5) S0100-40422010000200039.pdf.txt: 29986 bytes, checksum: 34751217eaffd2926281847a7376ad8d (MD5) Made available in DSpace on 2014-05-20T14:21:02Z (GMT). No. of bitstreams: 2 S0100-40422010000200039.pdf: 522843 bytes, checksum: 0f20f2fcc212e4ed940ae4f281938995 (MD5) S0100-40422010000200039.pdf.txt: 29986 bytes, checksum: 34751217eaffd2926281847a7376ad8d (MD5) Previous issue date: 2010-01-01 Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP) Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq) A simple and more environmentally friendly method by combined spot test-diffuse reflectance spectroscopy for determining metoclopramide in pharmaceutical formulations is described. The method is based on the reaction between metoclopramide and p-dimethylaminocinnamaldehyde, in the presence of HCl, producing a colored compound (λmáx = 580 nm) on the filter paper. The linear range was from 5.65 x 10-4-6.21x10-3 mol L-1 (r = 0.999). The limit of detection was 1.27 x 10-4 mol L-1. The proposed reflectometric method was applied successfully to the determination of metoclopramide in pharmaceuticals and it was favorably compared with the Brazilian or British Pharmacopoeia methods at 95% confidence level. Universidade Estadual Paulista Júlio de Mesquita Filho Instituto de Química do Campus de Araraquara Universidade Estadual Paulista Júlio de Mesquita Filho Instituto de Química do Campus de Araraquara |
| Databáze: | OpenAIRE |
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