Expression and correlation of Twist and gelatinases in breast cancer
| Autor: | Song Xue, Jin Huang, Yang Zhao, Liu Mingqiang, Zhengsheng Wu, Min Zhao, Qiang Zou, Hongguang Hu, Jin Wang, Gui-Zhu Li |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2013 |
| Předmět: |
Cancer Research
Pathology medicine.medical_specialty animal structures Metastasis Breast cancer Immunology and Microbiology (miscellaneous) medicine breast neoplasms Twist Tissue microarray Oncogene business.industry Cancer General Medicine Articles medicine.disease Molecular medicine matrix metalloproteinase 2 immunohistochemistry Cancer research Immunohistochemistry matrix metalloproteinase 9 pathology business gelatinases |
| Zdroj: | Experimental and Therapeutic Medicine |
| ISSN: | 1792-1015 1792-0981 |
| Popis: | Altered expression of Twist, matrix metalloproteinase (MMP)-2 and MMP-9 proteins has been identified in various types of human cancers. However, the correlation between Twist and these gelatinases in breast cancer remains unclear. In this study, immunohistochemical analysis of Twist, MMP-2 and MMP-9 expression was performed on tissue microarrays from 200 breast cancer cases. The association of Twist and gelatinase expression with clinicopathological factors and patient survival was analyzed. Altered expression of Twist, MMP-2 and MMP-9 proteins was observed in breast cancer tissue. The positive rates of Twist, MMP-2 and MMP-9 protein expression were 75.5, 97.0 and 96.0%, respectively. Increased expression of Twist was positively correlated with the status of axillary lymph node metastasis and higher tumor-node-metastasis (TNM) stage (P |
| Databáze: | OpenAIRE |
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