Adolescent Diet and Subsequent Serum Hormones, Breast Density, and Bone Mineral Density in Young Women: Results of the Dietary Intervention Study in Children Follow-up Study
Autor: | Joanne F. Dorgan, Frank Z. Stanczyk, Bruce A. Barton, Carolyn Y. Fang, Catherine Klifa, Linda Snetselaar, John A. Shepherd, Elizabeth H. Ruder, Lea Liu, John H. Himes, Norman L. Lasser, Kelley Pettee Gabriel, Andrea M. Kriska, Alan M. Robson, Nola M. Hylton, Linda Van Horn, Victor J. Stevens, Peter O. Kwiterovich |
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Rok vydání: | 2010 |
Předmět: |
Adult
medicine.medical_specialty Adolescent Bone density Epidemiology Saturated fat Physiology Breast Neoplasms Article law.invention Young Adult Breast cancer Sex hormone-binding globulin Randomized controlled trial Bone Density law Sex Hormone-Binding Globulin Internal medicine medicine Humans Breast Young adult Child Diet Fat-Restricted Progesterone Bone mineral Estradiol biology business.industry Cancer Cholesterol LDL medicine.disease Diet Endocrinology Oncology biology.protein Female business Gonadal Hormones Follow-Up Studies Mammography |
Zdroj: | Cancer Epidemiology, Biomarkers & Prevention. 19:1545-1556 |
ISSN: | 1538-7755 1055-9965 |
Popis: | Background: Adolescent diet is hypothesized to influence breast cancer risk. We evaluated the long-term effects of an intervention to lower fat intake among adolescent girls on biomarkers that are related to breast cancer risk in adults. Methods: A follow-up study was conducted on 230 girls who participated in the Dietary Intervention Study in Children (DISC), in which healthy, prepubertal, 8 to 10 year olds were randomly assigned to usual care or to a behavioral intervention that promoted a reduced fat diet. Participants were 25 to 29 years old at follow-up visits. All tests of statistical significance are two-sided. Results: In analyses that did not take account of diet at the time of the follow-up visit, the only statistically significant treatment group difference was higher bone mineral content in intervention group participants compared with usual care group participants; their mean bone mineral contents were 2,444 and 2,377 g, respectively. After adjustment for current diet, the intervention group also had statistically significantly higher bone mineral density and luteal phase serum estradiol concentrations. Serum progesterone concentrations and breast density did not differ by treatment group in unadjusted or adjusted analyses. Conclusions: Results do not support the hypothesis that consumption of a lower fat diet during adolescence reduces breast cancer risk via effects on subsequent serum estradiol and progesterone levels, breast density, or bone mineral density. It remains unclear, however, if the results are specific to the DISC intervention or are more broadly applicable. Impact: Modest reductions in fat intake during adolescence are unlikely to lower later breast cancer risk via long-term effects on the biomarkers measured. Cancer Epidemiol Biomarkers Prev; 19(6); 1545–56. ©2010 AACR. |
Databáze: | OpenAIRE |
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