Propranolol-induced Reverse Vascular Steal in Arteriopathic Patients
| Autor: | Sandro Betocchi, Giuseppe Paolo Ferulano, Mario Condorelli, Massimo Chiariello, Giuseppe Lavecchia, Salvatore Verrienti, Giampaolo Paudice, Sergio Abate, Gregorio Brevetti |
|---|---|
| Přispěvatelé: | G., Brevetti, M., Chiariello, Ferulano, GIUSEPPE PAOLO, Betocchi, Sandro, G., Paudice, G., Lavecchia, S., Abate, S., Verrienti, Condorelli, Mario |
| Rok vydání: | 1982 |
| Předmět: |
Arteriosclerosis
Vasodilator Agents Arterial Occlusive Diseases Blood Pressure Vasodilation Propranolol 030204 cardiovascular system & hematology Peripheral artheriopathy 03 medical and health sciences 0302 clinical medicine Heart Rate Ischemia Humans Medicine Plethysmograph Plethysmography Impedance 030212 general & internal medicine Aged Xanthinol Niacinate Leg business.industry vascular steal Blood flow Middle Aged IV injection Femoral Artery Radiography Shunting Anesthesia beta-blocker Blood supply medicine.symptom Cardiology and Cardiovascular Medicine business Blood Flow Velocity Vasoconstriction medicine.drug |
| Zdroj: | Scopus-Elsevier |
| ISSN: | 1940-1574 0003-3197 |
| DOI: | 10.1177/000331978203300202 |
| Popis: | The vascular steal phenomenon, i.e., the shunting of blood from ischemic to normally perfused areas, has been described in the affected limbs of arteriopathic patients after taking vasodilating drugs. This study was per formed to ascertain whether the reverse situation can be induced, i.e., whether vasoconstriction of the vessels supplying the nonischemic zone could increase the amount of blood reaching the ischemic area. Accordingly, 49 arteriopathic subjects were selected on the basis of the plethysmographic evidence of a reduction of blood flow in the affected limb following an IV injection of xanthinol-nicotinate. In a first group of 10 patients, the reduction of blood supply to the affected limb induced by xanthinol-nicotinate was inhibited when this drug was administered in combination with 5 mg of propranolol. In another 22 patients, the plethysmographic response observed after xanthinol-nicotinate alone was reversed when this drug was injected after 10 mg of propranolol. Actually, the blood perfusion to the affected limb rose significantly at all times of recording as compared to basal values. Finally, in a third group of 10 patients in whom xanthinol-nicotinate induced a significant reduction of blood flow, propranolol did not modify it. The angiographic studies performed in 3 patients confirm the plethysmographic results. Xanthinol-nicotinate alone induces a reduction of the vascular filling in the affected limb, while the combination of the vasodilating drug with 10 mg of propranolol is able to improve the vascular filling in the affected area. These results indicate that the overwhelming action of α-adrenoceptors obtained in the normal area by the β-receptors' blockade favors a beneficial redistribution of blood flow which might be considered a reverse vascular steal. |
| Databáze: | OpenAIRE |
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