CSF levels of glutamine synthetase and GFAP to explore astrocytic damage in seronegative NMOSD
| Autor: | Hayrettin Tumani, Ichiro Nakashima, Douglas Kazutoshi Sato, Iris Kleerekooper, S Anand Trip, Axel Petzold, Makbule Senel, Dagoberto Callegaro, Megan K. Herbert, Marcel M. Verbeek, H. Bea Kuiperij, Albert Saiz, Romain Marignier, Kazuo Fujihara, Brigit A. de Jong |
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| Přispěvatelé: | Neurology, Amsterdam Neuroscience - Neuroinfection & -inflammation, APH - Methodology, APH - Mental Health, Ophthalmology, APH - Quality of Care |
| Rok vydání: | 2020 |
| Předmět: |
Adult
Male Pathology medicine.medical_specialty Adolescent Myelin oligodendrocyte glycoprotein 03 medical and health sciences Young Adult 0302 clinical medicine Cerebrospinal fluid All institutes and research themes of the Radboud University Medical Center Glutamate-Ammonia Ligase Glutamine synthetase Glial Fibrillary Acidic Protein medicine Humans Optic neuritis 030304 developmental biology Aged Retrospective Studies 0303 health sciences Neuromyelitis optica Glial fibrillary acidic protein biology business.industry Multiple sclerosis Neuromyelitis Optica Middle Aged medicine.disease Disorders of movement Donders Center for Medical Neuroscience [Radboudumc 3] Psychiatry and Mental health Astrocytes biology.protein Biomarker (medicine) Surgery Female Neurology (clinical) business 030217 neurology & neurosurgery |
| Zdroj: | Journal of Neurology, Neurosurgery, and Psychiatry, 91, 6, pp. 605-611 Kleerekooper, I, Herbert, M K, Kuiperij, H B, Sato, D K, Fujihara, K, Callegaro, D, Marignier, R, Saiz, A, Senel, M, Tumani, H, De Jong, B A, Trip, S A, Nakashima, I, Verbeek, M M & Petzold, A 2020, ' CSF levels of glutamine synthetase and GFAP to explore astrocytic damage in seronegative NMOSD ', Journal of Neurology, Neurosurgery and Psychiatry, vol. 91, no. 6, 322286, pp. 605-611 . https://doi.org/10.1136/jnnp-2019-322286 Journal of Neurology, Neurosurgery, and Psychiatry, 91, 605-611 Journal of Neurology, Neurosurgery and Psychiatry, 91(6):322286, 605-611. BMJ Publishing Group |
| ISSN: | 0022-3050 |
| Popis: | ObjectiveTo explore levels of astrocytopathy in neuromyelitis optica spectrum disorder (NMOSD) by measuring levels of the astrocytic enzyme glutamine synthetase (GS) and glial fibrillary acidic protein (GFAP), an established astrocytic biomarker known to be associated with disease activity in multiple sclerosis.MethodsCerebrospinal fluid concentrations of GS and GFAP were measured by ELISA in patients with NMOSD (n=39, 28 aquaporin-4 (AQP4)-Ab-seropositive, 3 double-Ab-seronegative, 4 myelin oligodendrocyte glycoprotein (MOG)-Ab-seropositive and 4 AQP4-Ab-seronegative with unknown MOG-Ab-serostatus), multiple sclerosis (MS) (n=69), optic neuritis (n=5) and non-neurological controls (n=37).ResultsGFAP and GS concentrations differed significantly across groups (both ps=0.70, pConclusionsOur data indicate astrocytic injury occurs in some patients with double-Ab-seronegative NMOSD, which hints at the possible existence of yet undiscovered astrocytic autoimmune targets. We hypothesise that elevated GS and GFAP levels could identify those double-Ab-seronegative patients suitable to undergo in-depth autoimmune screening for astrocytic antibodies. |
| Databáze: | OpenAIRE |
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