Localization of the cell attachment region in types I and II collagens
| Autor: | Hynda K. Kleinman, Ermona B. McGoodwin, Robert J. Klebe |
|---|---|
| Rok vydání: | 1976 |
| Předmět: |
Cell
Chondrosarcoma Lathyrism Biophysics Peptide Biochemistry Chain (algebraic topology) medicine Animals Cyanogen Bromide Binding site Molecular Biology Cell attachment protein Skin chemistry.chemical_classification Binding Sites biology Chemistry Proteins Active site Neoplasms Experimental Cell Biology Peptide Fragments Rats Kinetics Cartilage medicine.anatomical_structure biology.protein Cattle Collagen Type I collagen Protein Binding |
| Zdroj: | Biochemical and Biophysical Research Communications. 72:426-432 |
| ISSN: | 0006-291X |
| DOI: | 10.1016/s0006-291x(76)80060-5 |
| Popis: | Summary The sites on type I and II collagen which bind to the cell attachment protein (CAP) have been identified using an inhibition assay. Both chains of type I collagen contain binding sites but αI(I) is more active than the α2 chain. The most active peptide obtained from the α1(I) chain corresponds to residues 568 through 835. A comparable region was found to be the only active site on the α1 (II) chain. |
| Databáze: | OpenAIRE |
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