Combined administration of alpha-erythropoietin and filgrastim can improve the outcome and cost balance of autologous stem cell transplantation in patients with lymphoproliferative disorders
| Autor: | Pietro Leoni, M C Masia, Guido Gini, GianMario Raggetti, M Troiani, Massimo Offidani, M Montanari, Antonella Poloni, Attilio Olivieri, Debora Capelli, Ilaria Scortechini, Moira Lucesole |
|---|---|
| Rok vydání: | 2004 |
| Předmět: |
Adult
Male medicine.medical_specialty Time Factors Blood transfusion Filgrastim Cost-Benefit Analysis medicine.medical_treatment Gastroenterology Group B Autologous stem-cell transplantation Internal medicine Granulocyte Colony-Stimulating Factor Humans Medicine Autologous transplantation Blood Transfusion Erythropoietin Multiple myeloma Aged Transplantation Platelet Count business.industry Hematology Middle Aged medicine.disease Lymphoproliferative Disorders Recombinant Proteins Granulocyte colony-stimulating factor Surgery Kinetics Treatment Outcome Multivariate Analysis Female Multiple Myeloma business Stem Cell Transplantation medicine.drug |
| Zdroj: | Bone Marrow Transplantation. 34:693-702 |
| ISSN: | 1476-5365 0268-3369 |
| DOI: | 10.1038/sj.bmt.1704643 |
| Popis: | We compared the use of G-CSF plus EPO in a group of 32 multiple myeloma and lymphoma patients with historical controls receiving G-CSF alone. Haemopoietic reconstitution was significantly faster in patients receiving G-CSF+EPO (group B), with a median time of 10 days to achieve an ANC count0.5 x 10(9)/l, compared to 11 days in the historical group (A). The median duration of severe neutropenia (ANC count100/ml) was significantly shorter in group B compared to group A; platelet counts20 x 10(9) and50 x 10(9)/l were achieved at days + 13 and + 17, respectively in group B, compared to days + 14 and + 24, respectively, in group A (P = 0.015, 0.002) patients. The transfusion requirement was reduced in group B, with 0 (0-6) RBC units and 1 (0-5) platelet unit transfused in group B vs 2 RBC (0-9) and 2 platelet units (0-8) in group A. Median days of fever, antibiotic therapy and hospital stay were reduced in group B (9.5 days vs 22). The mean cost of autotransplantation per group A patient was 23,988 Euro, compared with 18,394 Euro for a group B patient. Our study suggests that the EPO + G-CSF combination not only accelerates engraftment kinetics, but can also improve the clinical course of ASCT. |
| Databáze: | OpenAIRE |
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