Lymphoproliferative lesions in BB Wistar rats
| Autor: | W. Schürch, N. Kalant, Eleanor Colle, T.A. Seemayer |
|---|---|
| Rok vydání: | 1983 |
| Předmět: |
Male
Pathology medicine.medical_specialty Medullary cavity Endocrinology Diabetes and Metabolism Diabetes Mellitus Experimental Malignant lymphoma Endocrinology Plasmacytoid Lymphocytes medicine Animals Immunoblastic sarcoma B cell business.industry Altered immunity Rats Inbred Strains medicine.disease Rats Lymphoma Microscopy Electron Diabetes Mellitus Type 1 medicine.anatomical_structure Female Lymph Nodes Lymph business |
| Zdroj: | Metabolism. 32:97-100 |
| ISSN: | 0026-0495 |
| DOI: | 10.1016/s0026-0495(83)80020-1 |
| Popis: | Fifteen percent of long-term diabetic BB Wistar rats developed abdominal B cell lymphoproliferative lesions which ranged from minute mesenteric aggregates of plasma cells and lymphocytes to malignant lymphoma with features of immunoblastic sarcoma or plasma-cell lymphoma. Lymph nodes in younger BB Wistar rats, both diabetic and nondiabetic, demonstrated variable degrees, often extensive, of paracortical and medullary replacement by plasmacytoid lymphocytes and/or plasma cells. This study documents morphologic abnormalities in lymph nodes of BB Wistar rats, thus providing additional evidence of altered immunity in this model. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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