Association between quantitative lower limb arterial calcification and bilateral severe knee osteoarthritis
| Autor: | Yosuke Yamamoto, Hiromu Ito, Shuichi Matsuda, Shigeo Yoshida, Kohei Nishitani, Shinichi Kuriyama, Shinichiro Nakamura, Yugo Morita, Motoo Saito |
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| Rok vydání: | 2021 |
| Předmět: |
Male
medicine.medical_specialty medicine.diagnostic_test business.industry Computed tomography Osteoarthritis Osteoarthritis Knee medicine.disease Lower limb Arterial calcification Cross-Sectional Studies Lower Extremity Rheumatology Risk Factors Internal medicine medicine Cardiology Humans Metabolic syndrome Risk factor Tomography X-Ray Computed business |
| Zdroj: | Modern Rheumatology. 31:1059-1065 |
| ISSN: | 1439-7609 1439-7595 |
| Popis: | To investigate whether lower limb arterial calcification (LLAC) quantified using computed tomography (CT) was a risk factor for bilateral severe knee osteoarthritis (OA).This cross-sectional study included patients who were scheduled for surgical treatment of primary varus knee OA. Knee OA was evaluated using the Kellgren-Lawrence (KL) classification, KL grades 3 and 4 were defined as severe OA. The LLAC score in the bilateral whole leg CT was quantitatively measured and categorized into low or high groups based on the median value. A modified Poisson regression model was used to examine the relationship between the categorized LLAC score and the presence of bilateral severe knee OA with adjustment for possible confounders.Of a total of 252 patients examined, multivariable modified Poisson regression analysis showed a significant association between higher LLAC score and the presence of bilateral severe knee OA (adjusted risk ratio = 1.28; 95% confidence interval [CI], 1.12-1.48;LLAC was associated with bilateral severe knee OA, and the LLAC score may be a useful measurement to identify patients at risk of bilateral severe knee OA. |
| Databáze: | OpenAIRE |
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