MRI and PET/CT for evaluation of the pathological response to neoadjuvant chemotherapy in breast cancer: A systematic review and meta-analysis
| Autor: | Penghui Jin, Tiankang Guo, Liang Yao, Huimin Li, Xiaofei Li, Kehu Yang, Lidong Hu |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
Adult
medicine.medical_treatment Breast Neoplasms Pathological response Sensitivity and Specificity 030218 nuclear medicine & medical imaging 03 medical and health sciences 0302 clinical medicine Breast cancer Positron Emission Tomography Computed Tomography Outcome Assessment Health Care Humans Medicine In patient Breast Positron emission Aged PET-CT Chemotherapy medicine.diagnostic_test business.industry Magnetic resonance imaging General Medicine Middle Aged medicine.disease Magnetic Resonance Imaging Neoadjuvant Therapy Treatment Outcome ROC Curve Chemotherapy Adjuvant Area Under Curve 030220 oncology & carcinogenesis Meta-analysis Female Surgery business Nuclear medicine |
| Zdroj: | The Breast. 40:106-115 |
| ISSN: | 0960-9776 |
| Popis: | Background Neoadjuvant chemotherapy (NAC) has become an essential treatment for breast cancer. However, there is still no consensus on the best tool to evaluate pathological response to NAC. Methods Two reviewers systematically searched Cochrane, PubMed, EMBASE, Web of Science, and CBM (last updated in February 2017) for eligible articles. We independently screened and selected studies that conformed to the inclusion criteria and extracted the requisite data. Pooled sensitivity, specificity, and the area under the SROC curve were calculated to estimate the diagnostic accuracy of magnetic resonance imaging (MRI) and positron emission computed tomography (PET/CT). And the relative DOR (RDOR) was used to compare accuracy for levels of the covariable. Results Thirteen studies involving 575 patients who underwent MRI and 618 who underwent PET/CT were included in our analysis. The pooled sensitivity and specificity of MRI were 0.88 (95% CI: 0.78–0.94) and 0.69 (95% CI: 0.51–0.83), respectively. The corresponding values for PET/CT were 0.77 (95% CI: 0.58–0.90) and 0.78 (95% CI: 0.63–0.88), respectively. The area under the SROC curve for MRI and PET/CT were 0.88 and 0.84, respectively. And the RDOR = 1.44 (95% CI, 0.46–4.47 P = 0.83). Conclusion MRI had a higher sensitivity and PET/CT had a higher specificity in predicting the pathologic response after NAC in patients with breast cancer. According to the area under the SROC curve and anatomic discriminative resolution, MRI is the more suitable recommendation for predicting the pathologic response after NAC. |
| Databáze: | OpenAIRE |
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