Lung injury in mice induced by factors acting synergistically with inhaled particulate antigen
| Autor: | S.C. Birnbaum, Tamar Kadar, M. Pinto, G.M. Goldberg |
|---|---|
| Rok vydání: | 1979 |
| Předmět: |
Bordetella pertussis
Erythrocytes medicine.medical_treatment Immunology chemical and pharmacologic phenomena Lung injury Pathology and Forensic Medicine Mice Immune system Adjuvants Immunologic Antigen Animals Immunology and Allergy Medicine Antigens Lung Aerosols Air Pollutants biology Inhalation business.industry Sulfuric Acids biology.organism_classification Hemagglutinins medicine.anatomical_structure Agglutinins Female Nasal administration business Adjuvant |
| Zdroj: | Clinical Immunology and Immunopathology. 13:361-368 |
| ISSN: | 0090-1229 |
| DOI: | 10.1016/0090-1229(79)90076-x |
| Popis: | The pulmonary humoral immune response and pathologic changes caused by a combined aerogenic exposure of mice to an airborne contaminant (sulfuric acid, H 2 SO 4 ) or an adjuvant ( Bordetella pertussis ) in conjunction with a particulate antigen (sheep red blood cells, SRBC) were studied. Daily inhalation of H 2 SO 4 with consequent weekly intranasal instillation of SRBC induced severe pulmonary injury. Serum and bronchial wash hemagglutinating antibody titers reached higher levels in mice that were exposed to H 2 SO 4 aerosol. An adjuvant ( B. pertussis ) in conjunction with SRBC, instilled intranasally and followed by weekly SRBC intranasal immunization, produced pulmonary inflammation without exposure to H 2 SO 4 . This animal model allows study of the role of environmental factors acting synergistically with inhaled antigens in induction of various types of immune lung injury. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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