The anti-oxidant ebselen antagonizes the release of the apoptogenic factor cytochrome c induced by Fe2+/citrate in rat liver mitochondria
| Autor: | Alain Boireau, Saliha Moussaoui, Pierre Dubedat, Pierre-Alain Maréchal, Mireille Meunier |
|---|---|
| Rok vydání: | 2000 |
| Předmět: |
Azoles
Male Cytochrome Apoptosis Cytochrome c Group Mitochondria Liver Mitochondrion Atractyloside Isoindoles Antioxidants Permeability Lipid peroxidation Rats Sprague-Dawley chemistry.chemical_compound Organoselenium Compounds Butylated hydroxytoluene Animals Citrates Ferrous Compounds biology Ebselen General Neuroscience Adenine nucleotide translocator Cytochrome c Intracellular Membranes Rats chemistry Biochemistry Spectrophotometry biology.protein |
| Zdroj: | Neuroscience letters. 289(2) |
| ISSN: | 0304-3940 |
| Popis: | We studied the effects of ebselen (a seleno-organic anti-oxidant), on the release of the apoptogenic factor, cytochrome c, in two different experimental situations damaging mitochondria: (1) Fe2+/citrate, known to induce lipid peroxidation consecutively to an oxidative stress; and (2) atractyloside, a ligand of the adenine nucleotide translocator. The effects of ebselen were compared to those of butylated hydroxytoluene (BHT, an inhibitor of lipid peroxidation), and cyclosporine A (CsA, a classical pore antagonist). Ebselen, like BHT, inhibited Fe2+/citrate-induced release of cytochrome c, whereas CsA was inactive. On the contrary, neither ebselen nor BHT inhibited atractyloside-induced release of cytochrome c, whereas CsA was potently active. The antioxidant properties of ebselen may protect mitochondria from the consequences of the release of cytochrome c. Thus, it is suggested that the neuroprotective effect of ebselen previously demonstrated in humans and in animals may be due, at least in part, to a mitochondrial protection. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect