In vitro inactivation of SARS-CoV-2 by commonly used disinfection products and methods
| Autor: | Ge YiYue, Fan Jingjing, Li Fang, Wu Xiaosong, Zhang Liu-bo, Xu Yan, Wang Ling, Sun Hong, Cui Lunbiao, Zeng Xiaoyan, Guo Xiling, Chen Yin, Chi Ying |
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| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
0301 basic medicine
Ammonium bromide genetic structures Science viruses Disinfectant chemistry.chemical_element Chloride Article Virus 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine medicine Chlorine Humans 030212 general & internal medicine skin and connective tissue diseases Pandemics Chromatography Ethanol Multidisciplinary SARS-CoV-2 fungi virus diseases COVID-19 In vitro Disinfection Quaternary Ammonium Compounds body regions 030104 developmental biology chemistry Virus Inactivation Medicine Ammonium chloride Pathogens Disinfectants medicine.drug |
| Zdroj: | Scientific Reports Scientific Reports, Vol 11, Iss 1, Pp 1-9 (2021) |
| ISSN: | 2045-2322 |
| DOI: | 10.1038/s41598-021-82148-w |
| Popis: | Background Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) infection is currently a global pandemic, and there is a lack of laboratory studies targeting pathogen resistance.Objective To investigate the effect of selected disinfection products and methods on the inactivation of SARS-CoV-2.Methods We used quantitative suspension testing to evaluate the effectiveness of the disinfectant/method.Results Available chlorine of 250 mg/L, 500 mg/L, and 1000 mg/L required 20 min, 5 min, and 0.5 min to efficiently inactivate SARS-CoV-2, respectively. A 600-fold dilution of 17% concentration of di-N-decyldimethylammonium bromide (283 mg/L) and the same concentration of di-N-decyldimethylammonium chloride required only 0.5 min to efficiently inactivate the virus. Ethanol, at 30% concentration for 1 min, and 40% and above for 0.5 min, could efficiently inactivate SARS-CoV-2. Heat takes approximate 30 min at 56°C, or 10 min above 70°C, or 5 min above 90°C to inactivate the virus.Conclusions The chlorinated disinfectants, Di-N-decyldimethylammonium bromide / chloride, ethanol, and heat were effective in inactivating SARS-CoV-2. The response of SARS-CoV-2 to disinfectants is very similar to that of SARS-CoV. |
| Databáze: | OpenAIRE |
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