Secondary metabolites from the unripe pulp of Persea americana and their antimycobacterial activities
| Autor: | Ih-Sheng Chen, Chien-Fang Peng, Chu-Hung Lin, Ying-Chen Lu, Hsun-Shuo Chang |
|---|---|
| Rok vydání: | 2012 |
| Předmět: |
Persea
medicine.drug_class Ethyl acetate Fatty alcohol Microbial Sensitivity Tests Fractionation engineering.material Antimycobacterial Analytical Chemistry Mycobacterium tuberculosis chemistry.chemical_compound medicine Molecular Structure Traditional medicine biology Plant Extracts Pulp (paper) General Medicine Lauraceae biology.organism_classification Anti-Bacterial Agents chemistry Biochemistry Fruit engineering Fatty Alcohols Food Science |
| Zdroj: | Food Chemistry. 135:2904-2909 |
| ISSN: | 0308-8146 |
| Popis: | The fruits of Persea americana (Avocado) are nowadays used as healthy fruits in the world. Bioassay-guided fractionation of the active ethyl acetate soluble fraction has led to the isolation of five new fatty alcohol derivatives, avocadenols A-D (1-4) and avocadoin (5) from the unripe pulp of P. americana, along with 12 known compounds (6-17). These structures were elucidated by spectroscopic analysis. Among the isolates, avocadenol A (1), avocadenol B (2), (2R,4R)-1,2,4-trihydroxynonadecane (6), and (2R,4R)-1,2,4-trihydroxyheptadec-16-ene (7) showed antimycobacterial activity against Mycobacterium tuberculosis H(37)R(V)in vitro, with MIC values of 24.0, 33.8, 24.9, and 35.7 μg/ml, respectively. |
| Databáze: | OpenAIRE |
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