Critical review evaluating the pig as a model for human nutritional physiology
| Autor: | Nadia de Jager, David Val-Laillet, Isabelle Le Huërou-Luron, Jean-Paul Lallès, S.J. Koopmans, Eugeni Roura, T. Schuurman |
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| Přispěvatelé: | Centre for Nutrition and Food Sciences, Queensland Alliance for Agriculture and Food Innovation, University of Queensland [Brisbane], Animal Sciences Group, Wageningen University and Research Center (WUR), UAR 1189 Département Alimentation Humaine, Institut National de la Recherche Agronomique (INRA)-Alimentation Humaine (ALIM.H), PRES Université Nantes Angers Le Mans (UNAM)-PRES Université Nantes Angers Le Mans (UNAM)-Département Alimentation Humaine (DPT ALIM. H), Nutrition, Métabolismes et Cancer (NuMeCan), Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-Institut National de la Santé et de la Recherche Médicale (INSERM), Wageningen University and Research [Wageningen] (WUR), Alimentation Adaptations Digestives, Nerveuse et Comportementales (ADNC), Institut National de la Recherche Agronomique (INRA), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE) |
| Jazyk: | angličtina |
| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
Non-Nutritive Sweeteners modèle animal Animal Nutrition [SDV]Life Sciences [q-bio] Sus scrofa DVZ devazepide imagerie cerebrale Medicine (miscellaneous) Physiology Umami Nutritional neuroscience icv intracerebroventricular 0302 clinical medicine Glucagon-Like Peptide 1 Taste receptor Food intake BBB blood–brain barrier Nutritional Physiological Phenomena IAP intestinal alkaline phosphatase ComputingMilieux_MISCELLANEOUS GIT gastrointestinal tract 2. Zero hunger SUC sucrose FA fatty acid DBS deep-brain stimulation Nutrition and Dietetics Detacheringen VNS vagal nerve stimulation Microbiota Human microbiome GLU glucose Pig model prise alimentaire Diervoeding animal models TAS1R taste receptor type 1 HSP heat shock protein MAMP microbial-associated molecular pattern Models Animal Ghrelin Cholecystokinin nutrition humaine medicine.medical_specialty Nutrient sensing Biology CCK cholecystokinin Chemosensing 03 medical and health sciences TAS2R taste receptor type 2 PYY peptide YY microbiote Internal medicine medicine LPS lipopolysaccharide Animals Humans Peptide YY human nutrition Nutrition iv intravenous TR taste receptor swine 030104 developmental biology Human nutrition Endocrinology T1R taste 1 receptor AA amino acid GLP-1 glucagon-like peptide-1 030217 neurology & neurosurgery porc |
| Zdroj: | Nutrition Research Reviews Nutrition Research Reviews, Cambridge University Press (CUP), 2016, 29 (1), pp.60-90. ⟨10.1017/S0954422416000020⟩ Nutrition Research Reviews 29 (2016) 01 Nutrition Research Reviews, 29(01), 60-90 |
| ISSN: | 0954-4224 1475-2700 |
| Popis: | The present review examines the pig as a model for physiological studies in human subjects related to nutrient sensing, appetite regulation, gut barrier function, intestinal microbiota and nutritional neuroscience. The nutrient-sensing mechanisms regarding acids (sour), carbohydrates (sweet), glutamic acid (umami) and fatty acids are conserved between humans and pigs. In contrast, pigs show limited perception of high-intensity sweeteners and NaCl and sense a wider array of amino acids than humans. Differences on bitter taste may reflect the adaptation to ecosystems. In relation to appetite regulation, plasma concentrations of cholecystokinin and glucagon-like peptide-1 are similar in pigs and humans, while peptide YY in pigs is ten to twenty times higher and ghrelin two to five times lower than in humans. Pigs are an excellent model for human studies for vagal nerve function related to the hormonal regulation of food intake. Similarly, the study of gut barrier functions reveals conserved defence mechanisms between the two species particularly in functional permeability. However, human data are scant for some of the defence systems and nutritional programming. The pig model has been valuable for studying the changes in human microbiota following nutritional interventions. In particular, the use of human flora-associated pigs is a useful model for infants, but the long-term stability of the implanted human microbiota in pigs remains to be investigated. The similarity of the pig and human brain anatomy and development is paradigmatic. Brain explorations and therapies described in pig, when compared with available human data, highlight their value in nutritional neuroscience, particularly regarding functional neuroimaging techniques. |
| Databáze: | OpenAIRE |
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