New Brain Tumor Entities Emerge from Molecular Classification of CNS-PNETs
| Autor: | Tom Mikkelsen, Rogier Versteeg, Christelle Dufour, Jens Schittenhelm, Umut H. Toprak, Eleonora Aronica, Sariah Allen, Stefan M. Pfister, Arie Perry, Dominique Figarella-Branger, David T.W. Jones, Stephan Wolf, Irene Slavc, Christian Mawrin, Pieter Wesseling, Nada Jabado, Cynthia Cowdrey, David W. Ellison, Andreas von Deimling, Jörg Felsberg, Michael A. Grotzer, Pascale Varlet, Michael C. Frühwald, Volker Hovestadt, Timothy E. Van Meter, Gnanaprakash Balasubramanian, V. Peter Collins, Wolfram Scheurlen, Christian Hagel, Volkmar Hans, Johannes Gojo, Irina Leis, Michael D. Taylor, Catherine Keohane, Marco Prinz, Rachid Drissi, Maria Łastowska, Istvan Vajtai, Anne Jouvet, Sonika Dahiya, Marietta Wolter, Matthias Schlesner, Till Milde, Chris Jones, Pascal Johann, Kristian W. Pajtler, Anna Maria Buccoliero, Marina Ryzhova, David Scheie, Kenneth Aldape, Matija Snuderl, Martin Ebinger, Bret C. Mobley, Sebastian Brabetz, Joanna J. Phillips, Tarek Shalaby, Silvia Hofer, Christian Koelsche, Christel Herold-Mende, Barbara C. Worst, Martin U. Schuhmann, Jüri Reimand, Walter Berger, Stephan Frank, Diana Carvalho, Daniela Lötsch, Christof M. Kramm, Amar Gajjar, David Capper, Peter van Sluis, Ivo Buchhalter, Christine Haberler, Katja von Hoff, Stefan Rutkowski, Roland Eils, Martin Hasselblatt, Ulrich Schüller, Maryam Fouladi, Jochen Rößler, Guido Reifenberger, Brent A. Orr, Andrew S. Moore, Alan Mackay, Marc Remke, André O. von Bueren, Felix Sahm, Jan Koster, Karel Zitterbart, Dominik Sturm, Paul A. Northcott, Peter Lichter, Matthias A. Karajannis, Stefan Holm, Martin Sill, Wiesława Grajkowska, Stéphanie Puget, Felice Giangaspero, Marcel Kool, Reinhard Schneppenheim, Lynn Ann Forrester, Mariarita Santi, Torsten Pietsch, Camelia M. Monoranu, Richard Volckmann, Iris Fried, Matthew Schniederjan, Andrey Korshunov, Elke Pfaff, Rainer Grobholz, Jacques Grill |
|---|---|
| Přispěvatelé: | Pathology, CCA - Cancer biology, Heidelberg University Hospital [Heidelberg], St Jude Children's Research Hospital, Department of Neuropathology, Institute of Pathology, NN Burdenko Neurosurgical Institute (NNBNI), University of Toronto, The Institute of Cancer Research, Royal Cancer Hospital, University of California [San Francisco] (UC San Francisco), University of California (UC), Children's Hospital Medical Center, Children's Hospital Medical Center Cincinnatri, Università degli Studi di Roma 'La Sapienza' = Sapienza University [Rome] (UNIROMA), The Children's Memorial Health Institute, Cnopf’sche Kinderklinik, Universität Bonn = University of Bonn, Universitaetsklinikum Hamburg-Eppendorf = University Medical Center Hamburg-Eppendorf [Hamburg] (UKE), Medizinische Universität Wien = Medical University of Vienna, Hôpital neurologique et neurochirurgical Pierre Wertheimer [CHU - HCL], Hospices Civils de Lyon (HCL), Karolinska Institutet [Stockholm], Luzerner Kantonsspital, University of Freiburg [Freiburg], Cork University Hospital, Hadassah Hebrew University Medical Center [Jerusalem], Otto-von-Guericke-Universität Magdeburg = Otto-von-Guericke University [Magdeburg] (OVGU), Rigshospitalet [Copenhagen], Copenhagen University Hospital, Vanderbilt University [Nashville], Children’s Healthcare of Atlanta, Children’s Hospital of Philadelphia (CHOP ), Università degli Studi di Firenze = University of Florence (UniFI), Washington University in Saint Louis (WUSTL), University Medical Center Göttingen (UMG), Klinikum Augsburg, University Hospital Münster - Universitaetsklinikum Muenster [Germany] (UKM), Radboud University Medical Center [Nijmegen], Universitäts Klinikum Freiburg = University Medical Center Freiburg (Uniklinik), German Cancer Research Center - Deutsches Krebsforschungszentrum [Heidelberg] (DKFZ), Tübingen University Hospital [Germany], University Hospital Basel [Basel], Hirslanden Medical Center, University Hospital Berne, Medical Center Bielefeld, Masaryk University [Brno] (MUNI), Department of Pathology, University of Cambridge [UK] (CAM), University of Amsterdam [Amsterdam] (UvA), Hôpital d'Instruction des Armées Sainte Anne, Service de Santé des Armées, Institut Gustave Roussy (IGR), Département de cancérologie de l'enfant et de l'adolescent [Gustave Roussy], CHU Necker - Enfants Malades [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Centre de Recherches en Oncologie biologique et Oncopharmacologie (CRO2), Aix Marseille Université (AMU)- Hôpital de la Timone [CHU - APHM] (TIMONE)-Institut National de la Santé et de la Recherche Médicale (INSERM), University hospital of Zurich [Zurich], Virginia Commonwealth University (VCU), Biocenter University of Würzburg = Biozentrum der Universität Würzburg, Julius-Maximilians-Universität Würzburg (JMU), Heinrich Heine Universität Düsseldorf = Heinrich Heine University [Düsseldorf], New York University Langone Medical Center (NYU Langone Medical Center), NYU System (NYU), VU University Medical Center [Amsterdam], Henry Ford Hospital, The University of Texas M.D. Anderson Cancer Center [Houston], University of Queensland [Brisbane], McGill University = Université McGill [Montréal, Canada], Cellular and Computational Neuroscience (SILS, FNWI), University of California [San Francisco] (UCSF), University of California, Università degli Studi di Roma 'La Sapienza' = Sapienza University [Rome], University of Bonn, Otto-von-Guericke University [Magdeburg] (OVGU), Anna Meyer Children's Hospital and University of Florence, Freiburg University Medical Center, Masaryk University and University Hospital Brno, Julius-Maximilians-Universität Würzburg [Wurtzbourg, Allemagne] (JMU), ANS - Cellular & Molecular Mechanisms, APH - Amsterdam Public Health, AGEM - Amsterdam Gastroenterology Endocrinology Metabolism, CCA -Cancer Center Amsterdam, Oncogenomics, Other departments |
| Rok vydání: | 2016 |
| Předmět: |
Pathology
[SDV.NEU.NB]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC]/Neurobiology Astroblastoma Neuroectodermal Tumors Repressor Proteins / genetics CNS-PNETs Biochemistry Central Nervous System Neoplasms 0302 clinical medicine Neuroectodermal Tumors / diagnosis Central Nervous System Neoplasms / classification Central Nervous System Neoplasms / genetics Non-U.S. Gov't Child Tumor Suppressor Proteins / genetics Central Nervous System Neoplasms / pathology Research Support Non-U.S. Gov't food and beverages Forkhead Transcription Factors genetics and molecular biology neuroectodermal tumors central nervous system 3. Good health Gene Expression Regulation Neoplastic Neuroepithelial cell medicine.anatomical_structure 030220 oncology & carcinogenesis Sarcoma Signal Transduction tumor Repressor Proteins / chemistry medicine.medical_specialty Molecular Sequence Data Central nervous system Brain tumor [SDV.CAN]Life Sciences [q-bio]/Cancer Neuroectodermal Tumors / genetics Neuroectodermal Tumors / pathology Rare cancers Radboud Institute for Molecular Life Sciences [Radboudumc 9] Biology Research Support General Biochemistry Genetics and Molecular Biology N.I.H 03 medical and health sciences Research Support N.I.H. Extramural Forkhead Transcription Factors / genetics Proto-Oncogene Proteins Neuroblastoma Journal Article medicine Humans Amino Acid Sequence Neuroectodermal Tumors / classification Proto-Oncogene Proteins / genetics Medulloblastoma Biochemistry Genetics and Molecular Biology(all) Tumor Suppressor Proteins Gene Expression Profiling Extramural DNA Methylation medicine.disease Proto-Oncogene Proteins / chemistry Repressor Proteins Gene expression profiling Immunology Trans-Activators Central Nervous System Neoplasms / diagnosis ddc:004 030217 neurology & neurosurgery Genetics and Molecular Biology(all) |
| Zdroj: | Cell, Vol. 164, No 5 (2016) pp. 1060-1072 Cell, 164, 5, pp. 1060-72 Cell, 164(5), 1060-1072. Cell Press Sturm, D, Orr, B A, Toprak, U H, Hovestadt, V, Jones, D T W, Capper, D, Sill, M, Buchhalter, I, Northcott, P A, Leis, I, Ryzhova, M, Koelsche, C, Pfaff, E, Allen, S J, Balasubramanian, G, Worst, B C, Pajtler, K W, Brabetz, S, Johann, P D, Sahm, F, Reimand, J, Mackay, A, Carvalho, D M, Remke, M, Phillips, J J, Perry, A, Cowdrey, C, Drissi, R, Fouladi, M, Giangaspero, F, Lastowska, M, Grajkowska, W, Scheurlen, W, Pietsch, T, Hagel, C, Gojo, J, Loetsch, D, Berger, W, Slavc, I, Haberler, C, Jouvet, A, Holm, S, Hofer, S, Prinz, M, Keohane, C, Fried, I, Mawrin, C, Scheie, D, Mobley, B C, Schniederjan, M J, Santi, M, Buccoliero, A M, Dahiya, S, Kramm, C M, von Bueren, A O, von Hoff, K, Rutkowski, S, Herold-Mende, C, Fruehwald, M C, Milde, T, Hasselblatt, M, Wesseling, P, Roessler, J, Schueller, U, Ebinger, M, Schittenhelm, J, Frank, S, Grobholz, R, Vajtai, I, Hans, V, Schneppenheim, R, Zitterbart, K, Collins, V P, Aronica, E, Varlet, P, Puget, S, Dufour, C, Grill, J, Figarella-Branger, D, Wolter, M, Schuhmann, M U, Shalaby, T, Grotzer, M, van Meter, T, Monoranu, C-M, Felsberg, J, Reifenberger, G, Snuderl, M, Forrester, L A, Koster, J, Versteeg, R, Volckmann, R, van Sluis, P, Wolf, S, Mikkelsen, T, Gajjar, A, Aldape, K, Moore, A S, Taylor, M D, Jones, C, Jabado, N, Karajannis, M A, Eils, R, Schlesner, M, Lichter, P, von Deimling, A, Pfister, S M, Ellison, D W, Korshunov, A & Kool, M 2016, ' New Brain Tumor Entities Emerge from Molecular Classification of CNS-PNETs ', Cell, vol. 164, no. 5, pp. 1060-1072 . https://doi.org/10.1016/j.cell.2016.01.015 Cell Cell, 2016, 164, pp.1060-1072. ⟨10.1016/j.cell.2016.01.015⟩ Cell, Elsevier, 2016, 164, pp.1060-1072. ⟨10.1016/j.cell.2016.01.015⟩ Cell, 164, 1060-72 Cell, 164(5), 1060. Cell Press |
| ISSN: | 0092-8674 1097-4172 |
| DOI: | 10.1016/j.cell.2016.01.015 |
| Popis: | Item does not contain fulltext Primitive neuroectodermal tumors of the central nervous system (CNS-PNETs) are highly aggressive, poorly differentiated embryonal tumors occurring predominantly in young children but also affecting adolescents and adults. Herein, we demonstrate that a significant proportion of institutionally diagnosed CNS-PNETs display molecular profiles indistinguishable from those of various other well-defined CNS tumor entities, facilitating diagnosis and appropriate therapy for patients with these tumors. From the remaining fraction of CNS-PNETs, we identify four new CNS tumor entities, each associated with a recurrent genetic alteration and distinct histopathological and clinical features. These new molecular entities, designated "CNS neuroblastoma with FOXR2 activation (CNS NB-FOXR2)," "CNS Ewing sarcoma family tumor with CIC alteration (CNS EFT-CIC)," "CNS high-grade neuroepithelial tumor with MN1 alteration (CNS HGNET-MN1)," and "CNS high-grade neuroepithelial tumor with BCOR alteration (CNS HGNET-BCOR)," will enable meaningful clinical trials and the development of therapeutic strategies for patients affected by poorly differentiated CNS tumors. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|