| Autor: | Medve, Laura, Achilli, Silvia, Serna, Sonia, Zuccotto, Fabio, Varga, Norbert, Thépaut, Michel, Civera, Monica, Vivès, Corinne, Fieschi, Franck, Reichardt, Niels, Bernardi, Anna |
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| Přispěvatelé: | Università degli Studi di Milano [Milano] (UNIMI), Institut de biologie structurale (IBS - UMR 5075 ), Université Grenoble Alpes [2016-2019] (UGA [2016-2019])-Institut de Recherche Interdisciplinaire de Grenoble (IRIG), Direction de Recherche Fondamentale (CEA) (DRF (CEA)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Direction de Recherche Fondamentale (CEA) (DRF (CEA)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Centre National de la Recherche Scientifique (CNRS), CIC biomaGUNE, Glycotechnology Laboratory, University of Dundee, Università degli Studi di Milano = University of Milan (UNIMI), Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes [2016-2019] (UGA [2016-2019])-Institut de Recherche Interdisciplinaire de Grenoble (IRIG), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA) |
| Předmět: |
0301 basic medicine
Langerin carbohydrates Mannose Catalysis drug discovery 03 medical and health sciences chemistry.chemical_compound Glycomimetic C-type lectins microarrays Full Paper [SDV.BBM.BS]Life Sciences [q-bio]/Biochemistry Molecular Biology/Structural Biology [q-bio.BM] biology Chemistry Drug discovery Organic Chemistry Lectin General Chemistry Preferential binding Full Papers 3. Good health DC-SIGN 030104 developmental biology Biochemistry glycomimetics biology.protein DNA microarray |
| Zdroj: | Chemistry-A European Journal Chemistry-A European Journal, Wiley-VCH Verlag, 2018, 24 (54), pp.14448-14460. ⟨10.1002/chem.201802577⟩ Chemistry-A European Journal, 2018, 24 (54), pp.14448-14460. ⟨10.1002/chem.201802577⟩ Chemistry (Weinheim an Der Bergstrasse, Germany) |
| ISSN: | 0947-6539 1521-3765 |
| DOI: | 10.1002/chem.201802577⟩ |
| Popis: | International audience; A library of mannose- and fucose-based glycomimetics was synthesized and screened in a microarray format against a set of C-type lectin receptors (CLRs) that included DC-SIGN, DC-SIGNR, langerin, and dectin-2. Glycomimetic ligands able to interact with dectin-2 were identified for the first time. Comparative analysis of binding profiles allowed their selectivity against other CLRs to be probed. |
| Databáze: | OpenAIRE |
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