Meta-analysis of genome-wide linkage studies in BMI and obesity
| Autor: | Mariza de Andrade, Philippe Froguel, Steven Stone, Adebowale Adeyemo, Michael P. Stern, David A. Collier, Cathryn M. Lewis, Rector Arya, Catherine L. Saunders, Susan Redline, Miina Öhman, Anthony G. Comuzzie, Robert L. Hanson, Gerald S. Berenson, John Blangero, Benedetta D. Chiodini, Wei Chen, Lisa J. Martin, Lyle J. Palmer, Leena Peltonen, Amy Luke, Ingrid B. Borecki, Hong-Wen Deng, Pak C. Sham, Yvon C. Chagnon, M W Nash, R. Arlen Price, Heather M. Stringham, Mary F. Feitosa, Stephen T. Turner, Cisca Wijmenga, Sathanur R. Srinivasan, Michael Boehnke, Markus Perola, Ravindranath Duggirala, Patricia Huezo-Dias, Victor Abkevich, Ahmed H. Kissebah, Weidong Li, Johannes Hebebrand |
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| Přispěvatelé: | Groningen Institute for Gastro Intestinal Genetics and Immunology (3GI) |
| Jazyk: | angličtina |
| Rok vydání: | 2007 |
| Předmět: |
SCAN METAANALYSIS
hypertension Genetic Linkage Endocrinology Diabetes and Metabolism Medizin Medicine (miscellaneous) Locus (genetics) Quantitative trait locus FTO gene Childhood obesity Body Mass Index 03 medical and health sciences Diabetes mellitus genetics Endocrinology Genetic linkage OBSTRUCTIVE SLEEP-APNEA medicine Diabetes Mellitus Humans genetics Obesity SUSCEPTIBILITY LOCUS 030304 developmental biology METABOLIC SYNDROME Genetics 0303 health sciences adiposity Nutrition and Dietetics diabetes business.industry Genetic heterogeneity Genome Human 030305 genetics & heredity DIABETES-MELLITUS BIPOLAR DISORDER SEARCH METAANALYSIS medicine.disease meta-analysis BODY-MASS INDEX Meta-analysis CHILDHOOD OBESITY business QUANTITATIVE-TRAIT LOCI |
| Zdroj: | Obesity, 15(9), 2263-2275. Wiley-Blackwell |
| ISSN: | 1930-7381 |
| Popis: | Objective: The objective was to provide an overall assessment of genetic linkage data of BMI and BMI-defined obesity using a nonparametric genome scan meta-analysis. Research Methods and Procedures: We identified 37 published studies containing data on over 31,000 individuals from more than >10,000 families and obtained genome-wide logarithm of the odds (LOD) scores, non-parametric linkage (NPL) scores, or maximum likelihood scores (MLS). BMI was analyzed in a pooled set of all studies, as a subgroup of 10 studies that used BMI-defined obesity, and for subgroups ascertained through type 2 diabetes, hypertension, or subjects of European ancestry. Results: Bins at chromosome 13q13.2- q33.1, 12q23-q24.3 achieved suggestive evidence of linkage to BMI in the pooled analysis and samples ascertained for hypertension. Nominal evidence of linkage to these regions and suggestive evidence for 11q13.3-22.3 were also observed for BMI-defined obesity. The FTO obesity gene locus at 16q12.2 also showed nominal evidence for linkage. However, overall distribution of summed rank p values |
| Databáze: | OpenAIRE |
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