Comparative genome analysis reveals niche-specific genome expansion in Acinetobacter baumannii strains

Autor: Dayananda Siddavattam, Michael Gribskov, Harshita Yakkala, Devyani Samantarrai
Jazyk: angličtina
Rok vydání: 2019
Předmět:
Acinetobacter baumannii
Siderophore
Physiology
Pathology and Laboratory Medicine
Genome
Medicine and Health Sciences
Soil Microbiology
Genetics
0303 health sciences
Comparative Genomic Hybridization
Multidisciplinary
Acinetobacter
Virulence
Genomics
Phenotype
Body Fluids
Bacterial Pathogens
Chemistry
Blood
Medical Microbiology
Physical Sciences
Medicine
Anatomy
Pathogens
Research Article
Genotype
Science
Biology
Genome Complexity
Microbiology
03 medical and health sciences
Phenols
Gene
Microbial Pathogens
030304 developmental biology
Whole genome sequencing
Bacteria
030306 microbiology
Biofilm
Sputum
Chemical Compounds
Organisms
Biology and Life Sciences
Computational Biology
biochemical phenomena
metabolism
and nutrition
Comparative Genomics
biology.organism_classification
Genome Analysis
Mucus
Genes
Bacterial
Zdroj: PLoS ONE
PLoS ONE, Vol 14, Iss 6, p e0218204 (2019)
ISSN: 1932-6203
Popis: The nosocomial pathogen Acinetobacter baumannii acquired clinical significance due to the rapid development of its multi-drug resistant (MDR) phenotype. A. baumannii strains have the ability to colonize several ecological niches including soil, water, and animals, including humans. They also survive under extremely harsh environmental conditions thriving on rare and recalcitrant carbon compounds. However, the molecular basis behind such extreme adaptability of A. baumannii is unknown. We have therefore determined the complete genome sequence of A. baumannii DS002, which was isolated from agricultural soils, and compared it with 78 complete genome sequences of A. baumannii strains having complete information on the source of their isolation. Interestingly, the genome of A. baumannii DS002 showed high similarity to the genome of A. baumannii SDF isolated from the body louse. The environmental and clinical strains, which do not share a monophyletic origin, showed the existence of a strain-specific unique gene pool that supports niche-specific survival. The strains isolated from infected samples contained a genetic repertoire with a unique gene pool coding for iron acquisition machinery, particularly those required for the biosynthesis of acinetobactin. Interestingly, these strains also contained genes required for biofilm formation. However, such gene sets were either partially or completely missing in the environmental isolates, which instead harbored genes required for alternate carbon catabolism and a TonB-dependent transport system involved in the acquisition of iron via siderophores or xenosiderophores.
Databáze: OpenAIRE
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