Multifactor Analysis of Thyroid Stiffness in Graves Disease: A Preliminary Study
| Autor: | Hui Zhi, Shimei Li, Xinchuan Zhou, Shao-Yun Hao, Xin-Bao Zhao, Ningyi Jiang, Jiyi Yao |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
endocrine system
Shear wave elastography medicine.medical_specialty endocrine system diseases business.industry Graves' disease Thyroid Stiffness General Medicine medicine.disease 030218 nuclear medicine & medical imaging 03 medical and health sciences 0302 clinical medicine medicine.anatomical_structure 030220 oncology & carcinogenesis medicine Radiology Nuclear Medicine and imaging Radiology medicine.symptom business Value (mathematics) |
| Zdroj: | American Journal of Roentgenology. 212:950-957 |
| ISSN: | 1546-3141 0361-803X |
| DOI: | 10.2214/ajr.18.20414 |
| Popis: | The aim of this study was to evaluate the value of shear wave elastography (SWE) in Graves disease (GD) and to identify the potential factors influencing thyroid stiffness.A total of 207 subjects were enrolled and underwent SWE examination in the study, including 162 patients with GD and 45 healthy volunteers with normal thyroids, matched for age and sex. For all subjects, five measurements of elastic modulus values (SWE mean, SWE minimum, and SWE maximum of a 9-mm ROI) were performed on each thyroid lobe, and a mean value was calculated. The indicators including free three-triiodothyronine (FTThe elastic modulus values for patient with GD were significantly higher than those for healthy control subjects. The ROC AUC values for GD by SWE mean was 0.656, and the cutoff value was 15.45 kPa. The sensitivity and specificity were 56.8% and 71.1%, respectively. The duration of disease, thyroid size, isthmus thickness, and levels of TPO Ab, TG Ab, and TR Ab were positively correlated with SWE mean in GD. However, there was no correlation between age, FTQuantitative SWE helps in the diagnosis of GD. The duration of disease, thyroid size, isthmus thickness, and levels of thyroid autoantibodies (TPO Ab, TG Ab, and TR Ab) could influence thyroid stiffness of GD. |
| Databáze: | OpenAIRE |
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