Evaluation of transventricular placement of porcine small intestinal submucosa stent valves in the pulmonary position in juvenile sheep model
| Autor: | Guowei Meng, Fei Teng, Qiang Sun, Qingling Zhou, Yongshan Zhang |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
Pulmonary and Respiratory Medicine
medicine.medical_specialty Swine medicine.medical_treatment Heart Ventricles Pulsatile flow Heart Valve Diseases 030204 cardiovascular system & hematology Prosthesis Design 03 medical and health sciences 0302 clinical medicine Bicuspid valve medicine Alloys Animals cardiovascular diseases Thrombus Intestinal Mucosa Bioprosthesis Heart Valve Prosthesis Implantation Pulmonary Valve Lung Sheep medicine.diagnostic_test business.industry Transventricular Angiography Hemodynamics Stent equipment and supplies medicine.disease Small intestinal submucosa Surgery Disease Models Animal surgical procedures operative medicine.anatomical_structure 030228 respiratory system Echocardiography Heart Valve Prosthesis Stents Cardiology and Cardiovascular Medicine business |
| Zdroj: | Interactive cardiovascular and thoracic surgery. 27(2) |
| ISSN: | 1569-9285 |
| Popis: | Objectives We assessed the transventricular placement of porcine small intestinal submucosa (SIS) stent valves in a juvenile sheep model at the 3-month follow-up evaluation. Methods We constructed a pulmonary stent valve by suturing a porcine SIS bicuspid valve into a bell-shaped 'Z' nitinol stent and implanted 7 SIS stent valves transventricularly in the pulmonary position in 7 sheep. The function of the stent valves was assessed using a pulsatile flow simulation system in vitro. Haemodynamic, angiographic, echocardiographic, histologic and radiographic examinations were carried out before, immediately after implantation and 3 months after implantation. Results All SIS stent valves were successfully implanted in the pulmonary position in 7 sheep. Angiographic, echocardiographic, haemodyamic and macroscopic studies confirmed firm anchoring and good positioning of the stents immediately after implantation and at 3-month follow-up. All stent valves had good function immediately after implantation and at the end of the protocol, with the exception of 1 stent valve with mild stenosis detected at the end of the protocol. All SIS valves were free of calcifications and thrombus formation, and all stents were intact with no fractures and migration based on postmortem examination and X-radiography. Conclusions We demonstrated successful implantation of porcine SIS stent valves in the pulmonary position in sheep with excellent valve function at the 3-month follow-up evaluation. Porcine SIS has potential superiority as a pulmonary stent bioprosthetic valve material, and the bell-shaped nitinol stent has potential superiority as a frame for pulmonary stent valves. |
| Databáze: | OpenAIRE |
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