Membrane Interactions with Calcium Oxalate Crystals: Variation in Hemolytic Potentials with Crystal Morphology
| Autor: | John H. Wiessner, Gretchen S. Mandel, Neil S. Mandel |
|---|---|
| Rok vydání: | 1986 |
| Předmět: |
Calcium oxalate monohydrate crystals
Time Factors Calcium Oxalate Surface Properties business.industry Urology Erythrocyte Membrane Calcium oxalate dihydrate Mineralogy Crystal structure Crystal morphology Hemolysis Structure-Activity Relationship Membrane Water channel Calcium Oxalate Crystals Humans Medicine Crystallization business Nuclear chemistry CALCIUM OXALATE MONOHYDRATE |
| Zdroj: | Journal of Urology. 135:835-839 |
| ISSN: | 1527-3792 0022-5347 |
| DOI: | 10.1016/s0022-5347(17)45871-x |
| Popis: | Crystal-induced membranolysis of human red blood cells has been quantltated for calcium oxalate monohydrate and calcium oxalate dihydrate crystals. Calcium oxalate monohydrate crystals are significantly more membranolytic than calcium oxalate dihydrate crystals at constant surface area. If the crystal morphology of calcium oxalate monohydrate is altered by grinding, the lytic potential at constant surface area is markedly reduced. However, altered calcium oxalate dihydrate crystals are as lytic as natural calcium oxalate dihydrate crystals at constant surface area. Differences in the calcium oxalate monohydrate and dihydrate crystal structures, specifically the structural characteristics of the disordered water channel in calcium oxalate dihydrate, can explain these different membranolytic characteristics. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|