Mast Cell Functions Linking Innate Sensing to Adaptive Immunity
| Autor: | Johanna Kotrba, Jan Dudeck, Martin Voss, Konstantinos Katsoulis-Dimitriou, Anne Dudeck |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
dendritic cell
T-Lymphocytes Antigen-Presenting Cells Review Biology Lymphocyte Activation Immune system Immunity medicine Animals Humans biochemistry Mast Cells lcsh:QH301-705.5 Inflammation Innate immune system T cell adaptive immunity Acquired immune system Mast cell Immunity Innate antigen presentation medicine.anatomical_structure lcsh:Biology (General) mast cell Neuroscience |
| Zdroj: | Cells Cells, Vol 9, Iss 2538, p 2538 (2020) |
| Popis: | Although Mast cells are known as key drivers of type I allergic reactions, there is increasing evidence for their critical role in host defense. MCs do not only play an important role in initiating innate immune responses, but also influence the onset, kinetic and amplitude of the adaptive arm of immunity, or fine-tune the mode of the adaptive reaction. Intriguingly, MCs have been shown to affect T cell activation by direct interaction or indirectly by modifying properties of antigen-presenting cells, and can even modulate lymph node-borne adaptive responses remotely from the periphery. In this review, we provide a summary of recent findings that explain how MCs act as a link between the innate and the adaptive immunity, all the way from sensing inflammatory insult to orchestrating the final outcome of the immune response. |
| Databáze: | OpenAIRE |
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