Biokinetic model of radioiodine I-131 in nine thyroid cancer patients subjected to in-vivo gamma camera scanning: A simplified five-compartmental model

Autor: Yi-Shi Hwua, Ya-Hui Lin, Lung-Kwang Pan, Chao-Chun Huang, Samrit Kittipayak, Shan-Ying Wang
Jazyk: angličtina
Rok vydání: 2020
Předmět:
Male
Physiology
Lung and Intrathoracic Tumors
030218 nuclear medicine & medical imaging
law.invention
Iodine Radioisotopes
0302 clinical medicine
Thymic Tumors
law
Medicine and Health Sciences
Medicine
Tissue Distribution
Endocrine Tumors
Thyroid cancer
Gamma camera
Thyroid
Multidisciplinary
Stomach
Half-life
Middle Aged
Body Fluids
Chemistry
medicine.anatomical_structure
Oncology
030220 oncology & carcinogenesis
Physical Sciences
Female
Anatomy
Research Article
Chemical Elements
Iodine
Half-Life
Adult
Single Photon Emission Computed Tomography Computed Tomography
Science
Excretion
chemistry.chemical_element
Endocrine System
Surgical and Invasive Medical Procedures
Carcinomas
Models
Biological
03 medical and health sciences
In vivo
Differential Equations
Humans
Computer Simulation
Gamma Cameras
Thyroid Neoplasms
Aged
Body fluid
business.industry
Biology and Life Sciences
Cancers and Neoplasms
medicine.disease
Gastrointestinal Tract
Kinetics
chemistry
Thyroid Carcinomas
Radiopharmaceuticals
Physiological Processes
business
Nuclear medicine
Digestive System
Mathematics
Zdroj: PLoS ONE, Vol 15, Iss 5, p e0232480 (2020)
PLoS ONE
ISSN: 1932-6203
Popis: A five-compartmental biokinetic model of I-131 radioiodine based on in-vivo gamma camera scanning results was developed and successfully applied to nine thyroid cancer patients who were administered 1,110 MBq I-131 in capsules for the residual thyroid gland ablation. The I-131 solution activity among internal organs was analyzed via the revised biokinetic model of iodine recommended by the ICRP-30 and -56 reports. Accordingly, a five-compartmental (stomach, body fluid, thyroid, whole body, and excretion) model was established to simulate the metabolic mechanism of I-131 in thyroid cancer patients, whereas the respective four simultaneous differential equations were solved via a self-developed program run in MATLAB. This made it possible to provide a close correlation between MATLAB simulation results and empirical data. The latter data were collected through in-vivo gamma camera scans of nine patients obtained after 1, 4, 24, 48, 72, and 168 hours after radioactive I-131 administration. The average biological half-life values for the stomach, body fluid, thyroid, and whole body of thyroid cancer patients under study were 0.54±0.32, 12.6±1.8, 42.8±5.1, and 12.6±1.8 h, respectively. The corresponding branching ratios I12, I23, I25, I34, I42, and I45 as denoted in the biokinetic model of iodine were 1.0, 0.21±0.14, 0.79±0.14, 1.0, 0.1, and 0.9, respectively. The average values of the AT dimensionless index used to verify the agreement between empirical and numerical simulation results were 0.056±0.017, 0.017±0.014, 0.044±0.023, and 0.045±0.009 for the stomach, thyroid, body fluid + whole body, and total, respectively. The results obtained were considered quite instrumental in the elucidation of metabolic mechanisms in the human body, particularly in thyroid cancer patients.
Databáze: OpenAIRE
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