Quantal parameters of transmission at the frog neuromuscular junction
| Autor: | Dimitrie D. Branisteanu, Robert L. Volle |
|---|---|
| Rok vydání: | 1976 |
| Předmět: |
Pharmacology
Chemistry Models Neurological Rana pipiens Pharmacology toxicology Neuromuscular Junction General Medicine Anatomy Synaptic Transmission Acetylcholine Neuromuscular junction medicine.anatomical_structure Transmission (telecommunications) medicine Biophysics Animals Calcium Synaptic Vesicles Repetitive nerve stimulation Probability |
| Zdroj: | Naunyn-Schmiedeberg's Archives of Pharmacology. 295:103-108 |
| ISSN: | 1432-1912 0028-1298 |
| DOI: | 10.1007/bf00499440 |
| Popis: | Estimates of quantal release parameters at frog neuromuscular junctions showed that alterations in [Ca2+]o affected m (number of quanta), p (probability of quantal release) and n (stores of quanta available for release). The effect of [Ca2+]o depended upon the initial value for p. When p was low, raising [Ca2+]o increased m and p, but not n. However, when p was large, raising [Ca2+]o had no further effect on p but increased m and n. During prolonged repetitive nerve stimulation to cause a decrease in m, n was decreased and p was increased. This finding was attributed to a failure of transmitter mobilization to maintain the stores of transmitter available for release. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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