The 3p21.1-p21.3 Hereditary Vascular Retinopathy Locus Increases the Risk for Raynaud's Phenomenon and Migraine
| Autor: | Gisela M. Terwindt, Joost Haan, R.R. Frants, K R J Vanmolkot, A.M.J.M. van den Maagdenberg, S. Kheradmand Kia, E. E. Kors, P. T. V. M. De Jong, Michel D. Ferrari, Jouke J. Hottenga |
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| Přispěvatelé: | Ophthalmology |
| Rok vydání: | 2005 |
| Předmět: |
Adult
Male medicine.medical_specialty Adolescent Migraine Disorders Quantitative Trait Loci Locus (genetics) Comorbidity Risk Assessment 03 medical and health sciences Quantitative Trait Heritable 0302 clinical medicine Retinal Diseases Prevalence Humans Medicine Genetic Predisposition to Disease Sibling Child Genes Dominant Netherlands business.industry Haplotype Raynaud Disease Sequence Analysis DNA General Medicine Transmission disequilibrium test medicine.disease Pathophysiology Hereditary vascular retinopathy Surgery Phenotype Haplotypes Migraine Immunology 030221 ophthalmology & optometry Etiology Female Neurology (clinical) business 030217 neurology & neurosurgery |
| Zdroj: | Cephalalgia, 25(12), 1168-1172. SAGE Publications Ltd |
| ISSN: | 1468-2982 0333-1024 |
| DOI: | 10.1111/j.1468-2982.2005.00994.x |
| Popis: | Previously, we described a large Dutch family with hereditary vascular retinopathy (HVR), Raynaud's phenomenon and migraine. A locus for HVR was mapped on chromosome 3p21.1-p21.3, but the gene has not yet been identified. The fact that all three disorders share a vascular aetiology prompted us to study whether the HVR haplotype also contributed to Raynaud's phenomenon and migraine in this family. Whereas the parent-child transmission disequilibrium test (TDT) did not reach significance, the sibling TDT revealed that the HVR haplotype harbours a susceptibility factor for Raynaud's phenomenon and migraine. Identification of the HVR gene will improve the understanding of the pathophysiology of HVR, Raynaud's phenomenon and migraine. |
| Databáze: | OpenAIRE |
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