Additional value of advanced neurosonography and magnetic resonance imaging in fetuses at risk for brain damage

Autor: R. J. Vermeulen, J.I.P. de Vries, L S de Vries, M.M. van Weissenbruch, J I M L Verbeke, Inge A. Zonnenberg, B.J. van der Knoop, Lourens R. Pistorius
Přispěvatelé: Obstetrics and gynaecology, Pediatric surgery, Radiology and nuclear medicine, Amsterdam Gastroenterology Endocrinology Metabolism, Amsterdam Reproduction & Development (AR&D), AMS - Rehabilitation & Development, Klinische Neurowetenschappen, MUMC+: MA Med Staf Spec Neurologie (9), RS: MHeNs - R1 - Cognitive Neuropsychiatry and Clinical Neuroscience
Jazyk: angličtina
Rok vydání: 2020
Předmět:
ANOMALIES
INFANTS
CYTOMEGALOVIRUS-INFECTION
030218 nuclear medicine & medical imaging
0302 clinical medicine
Obstetrics and gynaecology
Pregnancy
Medicine
Prospective Studies
PRETERM TWINS
Netherlands
030219 obstetrics & reproductive medicine
Radiological and Ultrasound Technology
medicine.diagnostic_test
neurodevelopment
ultrasound
ABNORMALITIES
Ultrasound
Obstetrics and Gynecology
General Medicine
Magnetic Resonance Imaging
Original Papers
fetus
Female
Monochorionic twins
Radiology
medicine.symptom
acquired brain damage
MRI
medicine.medical_specialty
Brain damage
FETAL MRI
Nervous System Malformations
Ultrasonography
Prenatal
03 medical and health sciences
Predictive Value of Tests
Humans
Radiology
Nuclear Medicine and imaging
PRENATAL-DIAGNOSIS
Fetus
Original Paper
business.industry
CHORIONICITY
CENTRAL-NERVOUS-SYSTEM
Magnetic resonance imaging
medicine.disease
Reproductive Medicine
Brain Injuries
Coronal plane
neonate
business
Zdroj: Ultrasound in Obstetrics and Gynecology, 56(3), 348-358. John Wiley and Sons Ltd
Ultrasound in Obstetrics & Gynecology, 56(3), 348-358. Wiley
Ultrasound in Obstetrics & Gynecology
van der Knoop, B J, Zonnenberg, I A, Verbeke, J I M L, de Vries, L S, Pistorius, L R, van Weissenbruch, M M, Vermeulen, R J & de Vries, J I P 2020, ' Additional value of advanced neurosonography and magnetic resonance imaging in fetuses at risk for brain damage ', Ultrasound in Obstetrics and Gynecology, vol. 56, no. 3, pp. 348-358 . https://doi.org/10.1002/uog.21943
ISSN: 0960-7692
DOI: 10.1002/uog.21943
Popis: Objective To assess the additional value of fetal multiplanar (axial, coronal and sagittal) neurosonography and magnetic resonance imaging (MRI) to that of the standard axial ultrasound planes in diagnosing brain damage in fetuses at high risk.Methods This was a prospective, multicenter, observational study. Women were eligible for participation if their fetus was at risk for acquired brain anomalies. Risk factors were congenital infection, alloimmune thrombocytopenia, fetal growth restriction, trauma during pregnancy, fetal hydrops, monochorionic twins and prior ultrasound finding suggestive of an acquired brain anomaly. Examinations of the fetal brain before birth comprised axial ultrasound and advanced neurosonography biweekly and MRI once. After birth, neonatal cranial ultrasound was performed at 1SD below the mean were considered suspicious for neurodevelopmental sequelae.Results Fifty-six fetuses were examined, and in 39/56 fetuses, all fetal-imaging modalities were available. PVE/SI changes were observed in 6/39, 21/39 and 2/39 fetuses on axial ultrasound planes, multiplanar neurosonography and MRI, respectively. IVH was found in 3/39, 11/39 and 1/39 fetuses, and BGTE/SI changes in 0/39, 12/39 and 0/39 fetuses, respectively. Outcome was suspicious for neurodevelopmental sequelae in 13/46 infants at 1 year, and at 2 years, 41/41 children had scores within 1 SD of the mean on BSID-III and 20 had scores > 1 SD below the mean on the behavioral (5/38), sensory profile (17/37) and/or linguistic (6/39) questionnaires.Conclusions In this cohort of fetuses at risk for brain damage, the severity of acquired brain anomalies was limited. Nevertheless, multiplanar neurosonography detected more fetal PVE changes, IVH and/or BGTE changes compared to the standard axial ultrasound planes and MRI. Fetal MRI did not demonstrate any anomalies that were not seen on neurosonography. Neurodevelopmental outcome at 2 years of age showed no or mild impairment in most cases. (C) 2019 The Authors. Ultrasound in Obstetrics & Gynecology published by John Wiley & Sons Ltd on behalf of the International Society of Ultrasound in Obstetrics and Gynecology.
Databáze: OpenAIRE
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