Direct Photoexcitation of Benzothiazolines: Acyl Radical Generation and Application to Access Heterocycles
| Autor: | Hai-Bing Ye, Jun Xuan, Xiang-Kui He, Juan Lu, Lei Li |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
heterocycles
photochemistry Chemistry benzothiazolines Pharmaceutical Science Organic chemistry Combinatorial chemistry Radical cyclization Article Analytical Chemistry Photoexcitation QD241-441 Chemistry (miscellaneous) Drug Discovery Molecular Medicine Surface modification Molecule Physical and Theoretical Chemistry |
| Zdroj: | Molecules, Vol 26, Iss 6843, p 6843 (2021) Molecules Volume 26 Issue 22 |
| ISSN: | 1420-3049 |
| Popis: | An acyl radical generation and functionalization strategy through direct photoexcitation of benzothiazolines has been developed. The formed acyl radical species can either be trapped by quinoxalin-2-ones to realize their C(3)-H functionalization or trigger a cascade radical cyclization with isonitriles to synthesise biologically important phenanthridines. The synthetic value of this protocol can be further illustrated by the modification of quinoxalin-2-ones, containing important natural products and drug-based complex molecules. |
| Databáze: | OpenAIRE |
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