Maternal BMI, Peripheral Deiodinase Activity, and Plasma Glucose: Relationships Between White Women in the HAPO Study
| Autor: | Patrick M. Catalano, Donald R. Coustan, Geralyn Lambert-Messerlian, James E. Haddow, Boyd E. Metzger, Elizabeth E. Eklund, Glenn E. Palomaki |
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| Rok vydání: | 2019 |
| Předmět: |
Adult
Blood Glucose medicine.medical_specialty Endocrinology Diabetes and Metabolism Clinical Biochemistry Deiodinase 030209 endocrinology & metabolism Context (language use) Iodide Peroxidase Biochemistry White People Body Mass Index Young Adult 03 medical and health sciences 0302 clinical medicine Endocrinology Pregnancy Diabetes mellitus Internal medicine Humans Medicine Clinical Research Articles Retrospective Studies Glucose tolerance test 030219 obstetrics & reproductive medicine C-Peptide biology medicine.diagnostic_test business.industry Biochemistry (medical) Thyroid Pregnancy Outcome Fasting Glucose Tolerance Test medicine.disease Gestational diabetes Diabetes Gestational medicine.anatomical_structure Hyperglycemia biology.protein Female business Body mass index Hormone |
| Zdroj: | J Clin Endocrinol Metab |
| ISSN: | 1945-7197 0021-972X |
| DOI: | 10.1210/jc.2018-02328 |
| Popis: | Objectives Explore the maternal body mass index (BMI) relationship with peripheral deiodinase activity further. Examine associations between deiodinase activity, glucose, and C-peptide. Consider findings in the historical context of related existing literature. Design Identify fasting plasma samples and selected demographic, biophysical, and biochemical data from a subset of 600 randomly selected non-Hispanic white women recruited in the Hyperglycemia Adverse Pregnancy Outcomes (HAPO) study, all with glucose tolerance testing [545 samples sufficient to measure TSH, free T4 (fT4), and T3]. Exclude highest and lowest 1% TSH values (535 available for analysis). Assess deiodinase activity by using T3/fT4 ratios. Among women with and without gestational diabetes mellitus (GDM), compare thyroid measurements, C-peptide, and other selected data. Examine relationships independent of GDM status between BMI and thyroid hormones and between thyroid hormones and glucose and C-peptide. Results Levels of BMI, T3/fT4 ratio, and T3 were significantly higher among women with GDM (P = 0.01, 0.005, and 0.001, respectively). Irrespective of GDM status, maternal BMI was associated directly with both T3/fT4 ratio (r = 0.40, P < 0.001) and T3 (r = 0.34, P < 0.001) but inversely with fT4 (r = −0.21, P < 0.001). In turn, fasting thyroid hormone levels (most notably T3/fT4 ratio) were directly associated with maternal glucose [z score sum (fasting, 1, 2 hours); r = 0.24, P < 0.001] and with C-peptide [z score sum (fasting, 1 hour); r = 0.27, P < 0.001]. Conclusions Higher BMI was associated with increased deiodinase activity, consistent with reports from elsewhere. Increased deiodinase activity, in turn, was associated with higher glucose. Deiodinase activity accounts for a small percentage of z score sum glucose. |
| Databáze: | OpenAIRE |
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