Diagnosis of Hodgkin Lymphoma from Cell Block: A Reliable and Helpful Tool in 'Selected' Diagnostic Practice
Autor: | Paolo Graziano, Cristiano Carbonelli, Paola Parente, Illuminato Carosi, Claudia Covelli, Luca Mastracci, Magda Zanelli, Maurizio Zizzo, Giovanni Biancofiore, Domenico Trombetta, Marco Taurchini, Stefano Ascani, Marco Sperandeo |
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Jazyk: | angličtina |
Rok vydání: | 2020 |
Předmět: |
EBUS-FNA
medicine.medical_specialty Hodgkin lymphoma US-FNA cell block cytology non-Hodgkin lymphoma paraffin block tumor pathology Clinical Biochemistry 030209 endocrinology & metabolism Malignancy Article 03 medical and health sciences 0302 clinical medicine Cytology Conventional cytology medicine Cell block lcsh:R5-920 medicine.diagnostic_test business.industry medicine.disease Lymphoma Fine-needle aspiration Effusion 030220 oncology & carcinogenesis Radiology lcsh:Medicine (General) business |
Zdroj: | Diagnostics Diagnostics, Vol 10, Iss 748, p 748 (2020) Volume 10 Issue 10 |
Popis: | Background: The diagnosis of lymphoma requires surgical specimens to perform morphological evaluation, immunohistochemical and molecular analyses. Ultrasound-guided fine needle aspiration may represent an appropriate first approach to obtain cytological samples in impalpable lesions and/or in patients unsuitable for surgical procedures. Although cytology has intrinsic limitations, the cell block method may increase the possibility of achieving an accurate diagnosis. Methods: We retrospectively selected a total of 47 ultrasound-guided fine needle aspiration and drainage samples taken from patients with effusion and deep-seated lesions which are clinically suspicious in terms of malignancy. Results: In 27 cases, both cell block and conventional cytology were performed: 21/27 cell blocks were adequate for the diagnosis of lymphoma and suitable for immunocytochemistry and molecular analyses vs. 12/20 samples to which only conventional cytology was applied. Moreover, in five patients we were able to make a diagnosis of Hodgkin lymphoma with the cell block (CB) technique. Conclusions: Contrary to conventional cytology, the cell block method may allow immunocytochemistry and molecular studies providing useful information for the diagnosis and subtypization of lymphoma in patients unsuitable for surgical procedure or with deep-seated lesions or extra-nodal diseases additionally, it is a daily, simple and helpful approach. Moreover, we describe the usefulness of cell blocks in the diagnosis of Hodgkin lymphoma. |
Databáze: | OpenAIRE |
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