Diagnosis of Hodgkin Lymphoma from Cell Block: A Reliable and Helpful Tool in 'Selected' Diagnostic Practice

Autor: Paolo Graziano, Cristiano Carbonelli, Paola Parente, Illuminato Carosi, Claudia Covelli, Luca Mastracci, Magda Zanelli, Maurizio Zizzo, Giovanni Biancofiore, Domenico Trombetta, Marco Taurchini, Stefano Ascani, Marco Sperandeo
Jazyk: angličtina
Rok vydání: 2020
Předmět:
Zdroj: Diagnostics
Diagnostics, Vol 10, Iss 748, p 748 (2020)
Volume 10
Issue 10
Popis: Background: The diagnosis of lymphoma requires surgical specimens to perform morphological evaluation, immunohistochemical and molecular analyses. Ultrasound-guided fine needle aspiration may represent an appropriate first approach to obtain cytological samples in impalpable lesions and/or in patients unsuitable for surgical procedures. Although cytology has intrinsic limitations, the cell block method may increase the possibility of achieving an accurate diagnosis. Methods: We retrospectively selected a total of 47 ultrasound-guided fine needle aspiration and drainage samples taken from patients with effusion and deep-seated lesions which are clinically suspicious in terms of malignancy. Results: In 27 cases, both cell block and conventional cytology were performed: 21/27 cell blocks were adequate for the diagnosis of lymphoma and suitable for immunocytochemistry and molecular analyses vs. 12/20 samples to which only conventional cytology was applied. Moreover, in five patients we were able to make a diagnosis of Hodgkin lymphoma with the cell block (CB) technique. Conclusions: Contrary to conventional cytology, the cell block method may allow immunocytochemistry and molecular studies providing useful information for the diagnosis and subtypization of lymphoma in patients unsuitable for surgical procedure or with deep-seated lesions or extra-nodal diseases
additionally, it is a daily, simple and helpful approach. Moreover, we describe the usefulness of cell blocks in the diagnosis of Hodgkin lymphoma.
Databáze: OpenAIRE