Evaluation of an activated carbon disposal system for safe disposal of model prescription sedative medications
| Autor: | Ajay K. Banga, William Fowler, Andrew Korey, Behnam Dasht Bozorg, Carter R. Anderson |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
Drug
Prescription Drugs medicine.drug_class media_common.quotation_subject Water contamination lcsh:Medicine 02 engineering and technology 030226 pharmacology & pharmacy Article Environmental impact Temazepam 03 medical and health sciences 0302 clinical medicine Tap water Highly porous medicine Humans Hypnotics and Sedatives Medical Waste Disposal Medical prescription lcsh:Science Prescription Drug Misuse media_common Public health Multidisciplinary Alprazolam Waste management lcsh:R 021001 nanoscience & nanotechnology Zolpidem Accidental exposure Charcoal Sedative Environmental science lcsh:Q Adsorption 0210 nano-technology Activated carbon medicine.drug |
| Zdroj: | Scientific Reports Scientific Reports, Vol 10, Iss 1, Pp 1-7 (2020) |
| ISSN: | 2045-2322 |
| Popis: | Lack of a safe and convenient disposal method for expired and unused medications may lead to many problems such as accidental exposure, intentional misuse, and food and water contamination. Activated carbon can offer safe disposal of medications due to its highly porous structure, which exerts strong physical adsorption forces with chemicals. This study aimed to evaluate the efficiency of an activated carbon-based drug disposal system for deactivating three model sedative prescription medications. Deactivation was performed by mixing the medication, activated carbon, and tap water. Desorption was evaluated by exposing the deactivation system to wash-out solutions. Rapid, precise, accurate, and sensitive HPLC-UV method for each drug was successfully developed, validated and employed. Results of the 28-day deactivation study showed that on average, more than 94.00% of drugs were rapidly deactivated within 8 hours. All drugs reached more than 99.00% deactivation by the end of 28-day period. Desorption study demonstrated that all medications were retained by the system, with insignificant amount of drug (0.25%) leached into the washout solutions within 24 hours. In conclusion, activated carbon rapidly and successfully deactivated the medications tested, suggesting activated carbon-based drug disposal system provides a convenient, secure, and effective method for unused medication. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|